Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Molekulare Krankheitsprozesse und neue Therapiestrategien bei kolorektalen Karzinomen und Darmentzündungen

Publikationen

2016

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C. IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo. Gut. 2016 Jan 18. pii: gutjnl-2015-310374. doi: 10.1136/gutjnl-2015-310374. [Epub ahead of print] PMID: 26783184

2015

Benderska N, Dittrich AL, Knaup S, Rau TT, Neufert C, Wach S, Fahlbusch FB, Rauh M, Wirtz RM, Agaimy A, Srinivasan S, Mahadevan V, Rümmele P, Rapti E, Gazouli M, Hartmann A, Schneider-Stock R. miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. Inflamm Bowel Dis. 2015 Sep;21(9):2039-51. doi: 10.1097/MIB.0000000000000453. PMID: 26083618

Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut. 2015 Jul 24. pii: gutjnl-2015-310022. doi: 10.1136/gutjnl-2015-310022. [Epub ahead of print] PMID: 26209553

Steinmann S, Scheibe K, Erlenbach-Wuensch K, Neufert C, Schneider-Stock R. Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). Int J Oncol. 2015 Jul;47(1):5-15. doi: 10.3892/ijo.2015.2998. Epub 2015 May 11. Review. PMID: 25963636

Jantsch J, Schatz V, Friedrich D, Schröder A, Kopp C, Siegert I, Maronna A, Wendelborn D, Linz P, Binger KJ, Gebhardt M, Heinig M, Neubert P, Fischer F, Teufel S, David JP, Neufert C, Cavallaro A, Rakova N, Küper C, Beck FX, Neuhofer W, Muller DN, Schuler G, Uder M, Bogdan C, Luft FC, Titze J. Cutaneous na(+)
storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab. 2015 Mar 3;21(3):493-501.

2014

Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K,
Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C,
Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated
epithelial host defense during infectious colitis. J Immunol. 2014 Oct 1;193(7):3779-91.

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, AppC, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT,Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med. 2014 Mar;20(3):313-8. doi:10.1038/nm.3462. Epub 2014 Feb 23. PubMed PMID: 24562382.

2013

Neumann H, Vieth M, Günther C, Neufert C, Kiesslich R, Grauer M, Atreya R, Neurath MF. Virtual chromoendoscopy for prediction of severity and disease extent in patients with inflammatory bowel disease: a randomized controlled study. Inflamm Bowel Dis.2013 Aug;(9):1935-42. doi:10.1097/ MIB.0b013e318290550e. PubMed PMID: 23839228.

Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest. 2013 Apr 1;123(4):1428-43. doi: 10.1172/JCI63748. Epub 2013 Mar 15. PubMed PMID: 23549083; PubMed Central PMCID: PMC3613905.

Neufert C, Agaimy A, Neurath MF, Mudter J. Confocal laser endomicroscopy for the in vivo detection of gastric foveolar metaplasia in long-standing ulcerative colitis. Inflamm Bowel Dis. 2013 Apr;19(5):E77-8. doi:10.1097/ MIB.0b013e3182813499. PubMed PMID: 23493075.

Chakilam S, Gandesiri M, Rau TT, Agaimy A, Vijayalakshmi M, Ivanovska J, Wirtz RM, Schulze-Luehrmann J, Benderska N, Wittkopf N, Chellappan A, Ruemmele P, Vieth M, Rave-Fränk M, Christiansen H, Hartmann A, Neufert CAtreya R, Becker C, Steinberg P, Schneider-Stock R. Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells. Am J Pathol. 2013 Mar;182(3):1005-20. doi: 10.1016/j.ajpath.2012.11.026. PubMed PMID: 23438478.

Foersch S, Neufert C, Neurath MF, Waldner MJ. Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. Diagn Ther Endosc. 2013;2013:250641. doi: 10.1155/2013/250641. Epub 2013 Jan 15. PubMed PMID: 23401648; PubMed Central PMCID: PMC3562574.

Ältere Publikationen

Neumann H, Neufert C, Vieth M, Siebler J, Mönkemüller K, Neurath MF.
High-definition endoscopy with i-scan enables diagnosis of characteristic mucosal lesions in Whipple's disease. Endoscopy. 2012 May;44 Suppl 2 UCTN:E217-8.

Dornhoff H, Becker C, Wirtz S, Strand D, Tenzer S, Rosfa S, Neufert C, Mudter J, Markl J, Siebler J, Neurath MF. A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling. Gastroenterology. 2012 May;142(5):1183-1194.e4.

Neufert C, Vieth M, Mönkemüller K, Neurath MF, Neumann H. In vivo diagnosis
and characterisation of Whipple's disease. Lancet Infect Dis. 2011 Dec;11(12):970.

Waldner MJ, Wirtz S, Neufert C, Becker C, Neurath MF. Confocal laser
endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice. Nat Protoc. 2011 Sep 1;6(9):1471-81.

Neufert C, Agaimy A, Wacker J, Neumann H, Neurath MF, Raithel M. Diarrhoea and massive duodenal round cell infiltration in a 27-year-old HIV positive female. Gut. 2011 Nov;60(11):1486, 1526.

Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C,
Weigmann B, Vieth M, Rose-John S, Neurath MF. VEGF receptor signaling links
inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010 Dec 20;207(13):2855-68.

Neurath MF, Wittkopf N, Wlodarski A, Waldner M, Neufert C, Wirtz S, Günther C, Becker C. Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology. 2010 Dec;139(6):1837-1843.e1.

Neufert C, Pickert G, Zheng Y, Wittkopf N, Warntjen M, Nikolaev A, Ouyang W, Neurath MF, Becker C. Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle. 2010 Feb 15;9(4):652-5. Epub 2010 Feb 12.

Paradisi A, Maisse C, Coissieux MM, Gadot N, Lépinasse F, Delloye-Bourgeois C, Delcros JG, Svrcek M, Neufert C, Fléjou JF, Scoazec JY, Mehlen P. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17146-51.

Pickert G* und Neufert C*, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA,Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009 Jul 6;206(7):1465-72. *Gleichberechtigte Erstautorschaft.

Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF.
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009 Jan;136(1):257-67.

Neufert C, Becker C, Neurath MF. An inducible mouse model of colon
carcinogenesis for the analysis of sporadic and inflammation-driven tumor
progression. Nat Protoc. 2007;2(8):1998-2004. PubMed PMID: 17703211.


Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J,
Monteleone G, Rose-John S, Neurath MF, Becker C. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol. 2007 Aug 15;179(4):2041-5.

Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007 Jul;37(7):1809-16.

Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models
of intestinal inflammation. Nat Protoc. 2007;2(3):541-6.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M,
Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007 Mar 29;446(7135):557-61.

Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006 Sep 1;177(5):2760-4.

Neufert C, Pai RK, Noss EH, Berger M, Boom WH, Harding CV. Mycobacterium
tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J Immunol. 2001 Aug 1;167(3):1542-9. PubMed PMID: 11466375.

 
 
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