Medizin 1

Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Typ III Interferone bei Entzündung und Karzinogenese

Internationale Preise

Dr. Heike Dornhoff

Posterpreis 2012 DDW San Diego

1. Posterpreis 2010 Brno/Brünn



Ganslmayer M, Hagel A, Dauth W, Zopf S, Strobel D, Müller V, Uder M, Neurath MF, Siebler J. A large cohort of patients with hepatocellular carcinoma in a single European centre: aetiology and prognosis now and in a historical cohort. Swiss Med Wkly. 2014 Jan 22;144:w13900. doi: 10.4414/smw.2014.13900. PMID: 24452307


Koch S, Wein A, Siebler J, Boxberger F, Neurath MF, Harich HD, Hohenberger W, Dörje F. Antiemetic prophylaxis and frequency of chemotherapy-induced nausea and vomiting in palliative first-line treatment of colorectal cancer patients: the Northern Bavarian IVOPAK I Project. Support Care Cancer. 2013 Sep;21(9):2395-402. doi: 10.1007/s00520-013-1801-z. Epub 2013 Apr 9. PMID: 23568765

Wildner D, Boxberger F, Wein A, Wolff K, Albrecht H, Männlein G, Janka R, Amann K, Siebler J, Hohenberger W, Neurath MF, Strauß R. Granulomatous lung disease requiring mechanical ventilation induced by a single application of oxaliplatin-based chemotherapy for colorectal cancer: a case report. Case Rep Oncol Med. 2013;2013:683948. doi: 10.1155/2013/683948. Epub 2013 Apr 8. PMID: 23691384


Hundorfean G, Agaimy A, Chiriac MT, Rösler W, Mackensen A, Siebler J, Neurath MF. Highlighting crypt necrosis by using confocal laser endomicroscopy for the in vivo and real-time diagnosis of GI graft-versus-host disease. J Clin Oncol. 2012 Dec 10;30(35):e368-9. doi: 10.1200/JCO.2012.41.7493. Epub 2012 Oct 29. No abstract available. PMID: 23109705

Neumann H, Vieth M, Atreya R, Grauer M, Siebler J, Bernatik T, Neurath MF, Mudter J. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflamm Bowel Dis. 2012 Dec;18(12):2261-9. doi: 10.1002/ibd.22907. Epub 2012 Feb PMID: 22344873

Neumann H, Diebel H, Mönkemüller K, Nägel A, Wildner D, Vieth M, Siebler J, Neurath MF. Description of a new, endoscopic technique to remove the over-the-scope-clip in an ex vivo porcine model (with video). Gastrointest Endosc. 2012 Nov;76(5):1009-13. doi: 10.1016/j.gie.2012.07.036. PMID: 23078925

Dornhoff H, Becker C, Wirtz S, Strand D, Tenzer S, Rosfa S, Neufert C, Mudter J, Markl J, Siebler J, Neurath MF. A Variant of Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor Beta Signaling.Gastroenterology 2012;142:1183-1194.

Ältere Publikationen

Potential role of interferon-lambda in the treatment of inflammation and cancer: an update. Dornhoff H, Siebler J, Neurath MF. International Journal of Interferon, Cytokine and Mediator Research 2011:3 51-57.

Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis.
Siebler J, Wirtz S, Frenzel C, Schuchmann M, Lohse AW, Galle PR, Neurath MF. J Immunol. 2008 Jan 1;180(1):30-3.PMID: 18096999 [PubMed - indexed for MEDLINE]

Enhanced sensitivity to CD95-induced apoptosis in ob/ob mice.
Siebler J, Schuchmann M, Strand S, Lehr HA, Neurath MF, Galle PR.
Dig Dis Sci. 2007 Sep;52(9):2396-402. Epub 2007 Apr 6.PMID: 17415659 [PubMed - indexed for MEDLINE]

IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet. Siebler J, Wirtz S, Weigmann B, Atreya I, Schmitt E, Kreft A, Galle PR, Neurath MF. Gastroenterology. 2007 Jan;132(1):358-71. Epub 2006 Oct 21.PMID: 17241885 [PubMed - indexed for MEDLINE]
Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication. Siebler J, Protzer U, Wirtz S, Schuchmann M, Höhler T, Galle PR, Neurath MF. Eur J Gastroenterol Hepatol. 2006 Feb;18(2):167-74. PMID: 16394798 [PubMed - indexed for MEDLINE]
Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Finotto S, Siebler J, Hausding M, Schipp M, Wirtz S, Klein S, Protschka M, Doganci A, Lehr HA, Trautwein C, Khosravi-Far R, Strand D, Lohse A, Galle PR, Blessing M, Neurath MF. Gut. 2004 Mar;53(3):392-400. Erratum in: Gut. 2004 Jul;53(7):1058. Khosravi-Fahr R [corrected to Khosravi-Far]. PMID: 14960523 [PubMed - indexed for MEDLINE]

A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammation. Siebler J, Wirtz S, Klein S, Protschka M, Blessing M, Galle PR, Neurath MF. Hepatology. 2003 Dec;38(6):1573-80. PMID: 14647068 [PubMed - indexed for MEDLINE]

The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. Atreya I, Schimanski CC, Becker C, Wirtz S, Dornhoff H, Schnürer E, Berger MR, Galle PR, Herr W, Neurath MF. Gut. 2007 Nov;56(11):1572-8. Epub 2007 Jun 12.PMID: 17566017 [PubMed - indexed for MEDLINE]

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF. J Immunol. 2006 Sep 1;177(5):2760-4. PMID: 16920909 [PubMed - indexed for MEDLINE]

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