Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Dendritische Zellen in der Mukosalen Immunologie

Publikationen

2015

Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EA, Temmerman L. Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep. 2015 Oct 21;5:15414. doi: 10.1038/srep15414. PMID: 26486587

Montagna GN, Biswas A, Hildner K, Matuschewski K, Dunay IR. Batf3 deficiency proves the pivotal role of CD8α+ dendritic cells in protection induced by vaccination with attenuated Plasmodium sporozoites. Parasite Immunol. 2015 Aug 18. doi: 10.1111/pim.12222. [Epub ahead of print] PMID: 26284735

Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K. Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer. Gut. 2015 Apr 2. pii: gutjnl-2014-308227. doi: 10.1136/gutjnl-2014-308227. [Epub ahead of print] PMID: 25838550

2014

Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C, Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis. J Immunol. 2014 Oct 1;193(7):3779-91. doi: 10.4049/jimmunol.1303076. Epub 2014 Sep 3. PMID: 25187663

Übel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, Rieker RJ, Maier A, Neurath MF, Murphy KM, Finotto S. The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol. 2014 Jan;133(1):198-206.e1-9. doi: 10.1016/j.jaci.2013.09.049. Epub 2013 Nov 28. PMID: 24290279

Zirlik S, Wich C, Frieser M, Hildner K, Kleye C, Neurath MF, Fuchs FS. Public spirometry for primary prevention of COPD. J Eval Clin Pract. 2014 Feb;20(1):43-7. doi: 10.1111/jep.12077. Epub 2013 Aug 17. PMID: 23952257

2013

Fuchs FS, Zirlik S, Hildner K, Schubert J, Vieth M, Neurath MF. Confocal laser endomicroscopy for diagnosing lung cancer in vivo. Eur Respir J. 2013 Jun;41(6):1401-8. doi: 10.1183/09031936.00062512. Epub 2012 Sep 20. PMID: 22997220

2012

Zirlik S, Hildner KM, Neurath MF, Fuchs FS. Methylene blue-aided in vivo staining of central airways during flexible bronchoscopy. ScientificWorldJournal. 2012;2012:625867. doi: 10.1100/2012/625867. Epub 2012 Aug 1. PMID: 22919343

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012 Mar 2;148(5):1001-14. doi: 10.1016/j.cell.2012.01.040. Erratum in: Cell. 2014 Sep 11;158(6):1444. PMID: 22385964

2011

Edelson BT, Bradstreet TR, KC W, Hildner K, Herzog JW, Sim J, Russell JH, Murphy TL, Unanue ER, Murphy KM. Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. PLoS One. 2011;6(10):e25660. doi: 10.1371/journal.pone.0025660. Epub 2011 Oct 17. PMID:22065991

Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF. Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages. Gastroenterology. 2011 Dec;141(6):2026-38. doi: 10.1053/j.gastro.2011.08.032. Epub 2011 Aug PMID: 21875498

Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM. CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity. 2011 Aug 26;35(2):236-48. doi: 10.1016/j.immuni.2011.06.012. PMID: 21867927

Schliehe C, Redaelli C, Engelhardt S, Fehlings M, Mueller M, van Rooijen N, Thiry M, Hildner K, Weller H, Groettrup M. CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo. J Immunol. 2011 Sep 1;187(5):2112-21. doi: 10.4049/jimmunol.1002084. Epub 2011 Jul 27. PMID: 21795597

Fuchs FS, Zirlik S, Hildner K, Frieser M, Ganslmayer M, Schwarz S, Uder M, Neurath MF. Fluorescein-aided confocal laser endomicroscopy of the lung. Respiration. 2011;81(1):32-8. doi: 10.1159/000320365. Epub 2010 Aug 21. PMID: 20733287

Ältere Publikationen

Weber KS, Hildner K, Murphy KM, Allen PM. Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol. 2010 Sep 1;185(5):2836-46. doi: 10.4049/jimmunol.1000880. Epub 2010 Jul 23. PMID: 20656926

Bar-On L, Birnberg T, Lewis KL, Edelson BT, Bruder D, Hildner K, Buer J, Murphy KM, Reizis B, Jung S. CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14745-50. doi: 10.1073/pnas.1001562107. Epub 2010 Aug 2. PMID: 20679228

Edelson BT, Wumesh KC, Juang R, Koyama M, Klekotka PA, Sung SSJ, Murphy TL, Hildner K, Murphy KM (2010). Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8a+ conventional dendritic cells. Journal of Experimental Medicine; 207(4): 823-36.

Schraml BU,* Hildner K,*, Ise W, Lee WL, Smith WAE, Solomon B, Sahota G, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russel JH, Murphy TL, Murphy KM (2009). The AP-1 transcription factor Batf controls Th17 differentiation. Nature, 460(7253):405-9. (*Co Erstautoren)

Kohyama M, Ise W, Edelson BT, Wilker PR, Hildner K, Mejia C, Frazier WA, Murphy TL, Murphy KM (2009). Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature, 457(7227):318-21.

Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM (2008). Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science, 322 (5904):1097-100.

Hildner KM, Schirmacher P, Atreya I, Dittmayer M, Bartsch B, Galle PR, Wirtz S; Neurath MF (2007). Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis. Journal of Immunology 178(6):3427-36.

Sparks-Thissen RL, Braaten DC, Hildner K, Murphy TL, Murphy KM, Virgin HW 4th. (2005). CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFN- gamma. Virology, 338(2):201-208.

Sedy JR, Gavrieli M, Potter KG, Hurchla MA, Lindsley RC, Hildner K, Scheu S, Pfeffer K, Ware CF, Murphy TL, Murphy KM (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nature Immunology, 6(1): 90-98.

 
 
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