Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Patientenorientierte Forschung und innovative Therapiestrategien bei chronisch entzündlichen Darmerkrankungen

Publikationen

2016

Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G. High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients. J Crohns Colitis. 2016 Jan 27. pii: jjw012. [Epub ahead of print] PMID: 26818661

López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, Wirtz S, Thonn V, Watson AJ, Brakebusch C, Bergö M, Neurath MF, Atreya I. Rho-A prenylation and signaling link epithelial homeostasis to intestinal Inflammation. J Clin Invest. 2016 Feb 1;126(2):611-26. doi: 10.1172/JCI80997. Epub 2016 Jan 11. PMID: 26752649 

2015

Atreya R, Billmeier U, Rath T, Mudter J, Vieth M, Neumann H, Neurath MF. First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy. World J Gastroenterol. 2015 Dec 7;21(45):12963-9. doi: 10.3748/wjg.v21.i45.12963. PMID: 26668517

Atreya R, Neumann H, Neurath MF. [Update: chronic inflammatory bowel disease]. Dtsch Med Wochenschr. 2015 Nov;140(23):1762-72. doi: 10.1055/s-0041-106605. Epub 2015 Nov 19. Review. German. PMID: 26583823

Lamprecht G, Atreya R, Kreis ME, Siegmund B, Stallmach A. Inflammatory Bowel Diseases: Current Medical and Surgical Therapy. Viszeralmedizin. 2015 Aug;31(4):287-9. doi: 10.1159/000438767. Epub 2015 Aug 3. No abstract available. PMID: 26557838

Neumann H, Neurath MF, Atreya R. Endoscopic Therapy in Inflammatory Bowel Diseases. Viszeralmedizin. 2015 Aug;31(4):280-6. doi: 10.1159/000435851. Epub 2015 Aug 4. Review. PMID: 26557837

Hess A, Roesch J, Saake M, Sergeeva M, Hirschmann S, Neumann H, Dörfler A, Neurath MF, Atreya R. Functional Brain Imaging Reveals Rapid Blockade of Abdominal Pain Response Upon Anti-TNF Therapy in Crohn's Disease. Gastroenterology. 2015 Oct;149(4):864-6. doi: 10.1053/j.gastro.2015.05.063. Epub 2015 Aug 8. No abstract available. PMID: 26264347

Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut. 2015 Jul 24. pii: gutjnl-2015-310022. doi: 10.1136/gutjnl-2015-310022. [Epub ahead of print] PMID: 26209553

Neumann H, Neurath MF, Atreya R. [Endoscopic therapies in inflammatory bowel diseases]. MMW Fortschr Med. 2015 Jun;157(12):63-6. doi: 10.1007/s15006-015-3283-z. German. No abstract available. PMI 26099411

Srinivasan B, Focke-Tejkl M, Weber M, Pahr S, Baar A, Atreya R, Neurath MF, Vogelsang H, Huber WD, Valenta R. Usefulness of recombinant γ-gliadin 1 for identifying patients with celiac disease and monitoring adherence to a gluten-free diet. J Allergy Clin Immunol. 2015 Dec;136(6):1607-1618.e3. doi: 10.1016/j.jaci.2015.04.040. Epub 2015 Jun 13. PMID: 26078104

Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K. Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer. Gut. 2015 Apr 2. pii: gutjnl-2014-308227. doi: 10.1136/gutjnl-2014-308227. [Epub ahead of print] PMID: 25838550

Monteleone G, Neurath MF, Ardizzone S, Di Sabatino A, Fantini MC, Castiglione F, Scribano ML, Armuzzi A, Caprioli F, Sturniolo GC, Rogai F, Vecchi M, Atreya R, Bossa F, Onali S, Fichera M, Corazza GR, Biancone L, Savarino V, Pica R, Orlando A, Pallone F. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13. doi: 10.1056/NEJMoa1407250. PMID: 25785968

Rath T, Billmeier U, Waldner MJ, Atreya R, Neurath MF. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Arch Toxicol. 2015 Apr;89(4):541-54. doi: 10.1007/s00204-015-1461-5. Epub 2015 Jan 30. Review. PMID: 25632846

Tontini GE, Mudter J, Vieth M, Atreya R, Günther C, Zopf Y, Wildner D, Kiesslich R, Vecchi M, Neurath MF, Neumann H. Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn's disease: a pilot study. Endoscopy. 2015 May;47(5):437-43. doi: 10.1055/s-0034-1391226. Epub 2014 Dec 18. PMID: 25521573

Atreya R, Neurath MF. IBD pathogenesis in 2014: Molecular pathways controlling barrier function in IBD. Nat Rev Gastroenterol Hepatol. 2015 Feb;12(2):67-8. doi: 10.1038/nrgastro.2014.201. Epub 2014 Dec 2. Review. No abstract available. PMID: 25446731

Steiner S, Daniel C, Fischer A, Atreya I, Hirschmann S, Waldner M, Neumann H, Neurath M, Atreya R, Weigmann B. Cyclosporine A regulates pro-inflammatory cytokine production in ulcerative colitis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):53-63. doi: 10.1007/s00005-014-0309-7. Epub 2014 Aug 26. PMID: 25155925  

2014

Atreya R, Neurath MF. Novel imaging modalities for immune cell monitoring in the intestine. Curr Opin Gastroenterol. 2014 Nov;30(6):553-8. doi: 10.1097/MOG.0000000000000120. Review. PMID: 25197780

Atreya R, Bülte M, Gerlach GF, Goethe R, Hornef MW, Köhler H, Meens J, Möbius P, Roeb E, Weiss S; ZooMAP Consortium. Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis. Int J Med Microbiol. 2014 Oct;304(7):858-67. doi: 10.1016/j.ijmm.2014.07.006. Epub 2014 Jul 25. Review. PMID: 25128370

Albrecht H, Naegel A, Hagel A, Roesler W, Foertsch T, Neurath MF, Atreya R, Raithel M. Over-the-scope-clipping in colonic perforation caused small-bowel fixation and pneumoperitoneum requiring surgical repair. Endoscopy. 2014;46 Suppl 1 UCTN:E314-5. doi: 10.1055/s-0034-1377218. Epub 2014 Jul 24. No abstract available. PMID: 25058829

Eftekhari P, Glaubitz L, Breidert M, Neurath MF, Atreya R. Physiological intermolecular modification spectroscopy for the prediction of response to anti-tumor necrosis factor therapy in patients with inflammatory bowel diseases. Dig Dis. 2014;32(4):446-54. doi: 10.1159/000358151. Epub 2014 Jun PMID: 24969293

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, App C, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med. 2014; 20: 313-8. 

Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT, Atreya R, Krauss E, Hundorfean G, Fichtner-Feigl S, Hartmann A, Becker C, Mudter J. IL-9 and ist receptor are predominantly involved in the pathogenesis of UC. Gut. 2014 Jun 23.

Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol.  2014; 15: 676-86.

2013

Atreya R, Goetz M.  Molecular imaging in gastroenterology. Nat Rev Gastroenterol Hepatol. 2013; Jul 16. doi: 10.1038/nrgastro.2013.125. [Epub ahead of print]

Schürmann S, Foersch S, Atreya R, Neumann H, Friedrich O, Neurath MF, Waldner MJ. Label-Free Imaging of Inflammatory Bowel Disease Using Multiphoton Microscopy.  Gastroenterology. 2013; Jul 11.
 
Neumann H, Vieth M, Günther C, Neufert C, Kiesslich R, Grauer M, Atreya R, Neurath MF. Virtual chromoendoscopy for prediction of severity and disease extent in patients with inflammatory bowel disease: a randomized controlled study. Inflamm Bowel Dis. 2013; 19: 1935-42.
 
Atreya R, Neumann H, Neurath MF. [Rational treatment of Crohn's disease]. MMW  Fortschr Med. 2013; 155: 61-3.
 
Neumann H, Vieth M, Fry LC, Günther C, Atreya R, Neurath MF, Mönkemüller K. Learning curve of virtual chromoendoscopy for the prediction of hyperplastic and adenomatous colorectal lesions: a prospective 2-center study. Gastrointest Endosc. 2013. [Epub ahead of print].

Neumann H, Günther C, Vieth M, Grauer M, Wittkopf N, Mudter J, Becker C, Schoerner C, Atreya R, Neurath MF. Confocal laser endomicroscopy for in vivo diagnosis of Clostridium difficile associated colitis - a pilot study. PLoS One. 2013; 8: e58753.

Chakilam S, Gandesiri M, Rau TT, Agaimy A, Vijayalakshmi M, Ivanovska J, Wirtz RM, Schulze-Luehrmann J, Benderska N, Wittkopf N, Chellappan A, Ruemmele P, Vieth M, Rave-Fränk M, Christiansen H, Hartmann A, Neufert C, Atreya R, Becker C, Steinberg P, Schneider-Stock R. Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells. Am J Pathol. 2013; 182: 1005-20.

Atreya R, Neumman H, Neurath MF. Rationale Therapie der Colitis ulcerosa. Wann lokal, wann systemisch, wann operativ behandlen? MMW Fortschritte der Medizin. Vol. 154. 13: 76-78.

2012

Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B. Transcription Factor NFATc2 Controls the Emergence of Colon Cancer Associated with IL-6 Dependent Colitis. Cancer Res. 2012; [Epub ahead of print].

Neumann H, Vieth M, Neurath MF, Atreya R. Endocytoscopy allows accurate in vivo differentiation of mucosal inflammatory cells in IBD: A pilot study. Inflamm Bowel Dis. 2012; 29: [Epub ahead of print].

Teichgräber U, Atreya I, Atreya R, Schwab M, Neurath MF. Infliximab treatment induces levels of the active azathioprine metabolite TGTP in Crohn's disease. Inflamm Bowel Dis. 2012; Apr 24. doi: 10.1002/ibd.22998 [Epub ahead of print].

Neumann H, Vieth M, Atreya R, Bernatik T, Mudter J, Neurath MF. Inverted diverticulum or adenomatous lesion? Identification using confocal laser endomicroscopy. Gastrointest Endosc. 2012; 75: 1102.

Neumann H, Wittkopf N, Atreya R, Becker C, Vieth M, Neurath MF. Advancedendoscopic imaging: from the top of the fold to the single bacterium. Gastrointest Endosc. 2012; 75: 1268-1269.
 
Hundorfean G, Agaimy A, Atreya R, Mudter J, Neurath MF, Neumann H. Confocal laser endomicroscopy for characterization of Crohn's disease-associated duodenitis. Endoscopy. 2012; 44: Suppl 2 UCTN:E80.
 
Hundorfean G, Atreya R, Agaimy A, Heinzerling L, Kämpgen E, Schuler G, Neurath MF. Fluorescein-guided confocal laser endomicroscopy for the detection of ipilimumab-induced colitis. Endoscopy. 2012; 44: Suppl 2.

Neumann H, Vieth M, Atreya R, Grauer M, Siebler J, Bernatik T, Neurath MF, Mudter J. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflamm Bowel Dis. 20122. [Epub ahead of print].

Neumann H, Mönkemüller K, Günther C, Atreya R, Vieth M, Neurath MF. Advanced endoscopic imaging for diagnosis of Crohn's disease. Gastroenterol Res Pract. 2012; 301541.

Ältere Publikationen

Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF. Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14(+) Macrophages. Gastroenterology. 2011; 141: 2026-38. Epub 2011 Aug 27.

Neumann H, Vieth M, Atreya R, Neurath MF, Mudter J. Prospective evaluation of  the learning curve of confocal laser endomicroscopy in patients with IBD. Histol Histopathol. 2011; 26: 867-72.

Neumann H, Fuchs FS, Vieth M, Atreya R, Siebler J, Kiesslich R, Neurath MF. Review article: in vivo imaging by endocytoscopy. Aliment Pharmacol Ther. 2011; 33:1183-93.

Neumann H, Vieth M, Atreya R, Mudter J, Neurath MF. First description of eosinophilic esophagitis using confocal laser endomicroscopy (with video). Endoscopy. 2011; 43: Suppl 2: E66.

Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010; 207: 2855-68.

Atreya R, Waldner MJ, Neurath MF. Molecular imaging: interaction between basic and clinical science. Gastroenterol Clin North Am. 2010; 39: 911-22.

Holtmann MH, Barreiros AP, Mudter J, Atreya R, Galle PR, Terkamp C, Gebel M. [Ultrasound education by simulator training--analysis of the largest simulator-based training in Germany]. Z Gastroenterol. 2010; 48: 1279-84.

Atreya R, Neurath MF. Chemokines in inflammatory bowel diseases. Dig Dis. 2010; 28: 386-94.

Atreya R, Neurath MF. Inflammation, Peptides and Biological Therapy. Dig Dis. 2009. 27 (suppl1): 42-47.

Atreya R, Neurath MF. New therapeutic strategies for treatment of inflammatory bowel disease. Mucosal Immunol. 2008; 1: 175-82.

Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF. The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest. 2008; 118: 2415-26.

Atreya I, Atreya R, Neurath MF. NF-kappaB in inflammatory bowel disease. J Intern Med. 2008; 263: 591-6.

Atreya R, Neurath MF. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets. 2008; 9: 369-74.

Goetz M*, Atreya R*, Ghalibafian M, Galle PR, Neurath MF. Exacerbation of ulcerative colitis after rituximab salvage therapy. Inflam Bowel Dis. 2007; 13: 1365-8. *Authors contributed equally

Atreya R, Atreya I, Neurath MF. Novel signal transduction pathways: analysis of STAT-3 and Rac-1 signaling in inflammatory bowel disease. Ann N Y Acad Sci. 2006; 1072: 98-113.

Atreya R, Neurath MF. Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol. 2005; 28: 187-96.

Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D, Lehr HA, Wirtz S, Becker C, Atreya R, Mudter J, Hildner K, Bartsch B, Holtmann M, Blumberg R, Walczak H, Iven H, Galle PR, Ahmadian MR, Neurath MF. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003; 111: 1133-45.

Finotto S, De Sanctis GT, Lehr HA, Herz U, Buerke M, Schipp M, Bartsch B, Atreya
R, Schmitt E, Galle PR, Renz H, Neurath MF. Treatment of allergic airway inflammation and hyper¬responsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med. 2001; 193: 1247-60.

Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, Fischer M, Neurath MF, Rose-John S. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem. 2001; 268: 160-7.

Atreya R, Mudter J*, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schurmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn’s disease and experimental colitis in vivo. Nat Med. 2000; 6: 583-8.

Buchbeiträge

Atreya R, Neurath MF. The normal intestinal mucosa: a state of “controlled” inflammation. Targan SR, Shanahan F, Karp LC (eds.): Inflammatory Bowel Disease: Translating Basic Science into Clinical Practice. 2010. Wiley-Blackwell. Chapter 6.

Atreya R, Neurath MF. The Role of the JAK/STAT Pathway in Inflammatory Bowel Diseases. Stephanou A (ed.): JAK-STAT Pathway in Disease. 2009. Landes Bioscience. Chapter 7, 90-99.

Atreya R, Neurath MF. Future Trends in Confocal Laser Endomicroscopy: Improved Imaging Quality and Immunoendoscopy. Kiesslich R, Galle PR, Neurath MF (eds.): Atlas of Endomicroscopy. 2008. Springer Medizin Verlag Heidelberg. Chapter 10, 93-100.

Neurath MF, Becker C, Mudter J, Atreya R, Hildner K, Wirtz S, Finotto S. New cytokines and their impact in mucosal pathogenesis. Andus T (ed.): Cytokines and cell homeostasis in the gastrointestinal tract. 2000. Kluwer Academic Publishers. Chapter 4, 31-34.

Neurath MF, Becker C, Mudter J, Atreya R, Hildner K, Wirtz S, Finotto S. Immunotherapeutic approaches in inflammatory bowel diseases. Rogler G (ed.): IBD at the end of its first century. 2000. Kluwer Academic Publishers. Chapter 4, 62-65.

Preise

2014      Theodor-Frerichs-Preis, Deutsche Gesellschaft für Innere Medizin (DGIM)
               
2012      „Spitzen-Abstract“, Gesellschaft für Gastroenterologie in Bayern  (GFGB)

2012      Oral Free-Paper Price, United European Gastroenterology Federation (UEGW)

2011      Oral Free-Paper Price, United European Gastroenterology Federation (UEGW)

2009      Ludwig-Demling-Forschungspreis, Deutsche Morbus Crohn/ Colitis ulcerosa Vereinigung e.V. (DCCV)

2004      Förderpreis, Boehringer Ingelheim Stiftung

2000      3. Preis der freien Vorträge, Deutsche Gesellschaft für Innere Medizin (DGIM)

1999      Förderungsstipendium des Fachbereichs Medizin, Johannes Gutenberg-Universität Mainz

 
 
  •  
  •  
  •  
  •  
  •  
 
 
 
Bitte tragen Sie Ihren Namen und gültige E-Mail-Adresse(n) ein!
X zum Schließen

Zusammenfassung