In recent years, the prevalence of food allergies has significantly increased. The activation of the immune system in the gastrointestinal tract can sometimes lead to severe food intolerances in the case of a genetic predisposition. The proof of this intestine-associated allergy is usually not possible by common blood and skin tests. A method used locally in the gastrointestinal tract would facilitate the detection of food sensitisation and allow a more valid diagnosis. Previously published, locally applied diagnostic procedures are not suitable for use in clinical routine due to the extended examination duration and the susceptibility to failure. Our goal is to establish a reliable and practicable method for the detection of food allergies mediated locally on the intestinal mucosa.