Medizin 1

Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Neurogastroenterologie und Neuroimmunologie



Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K, Wirtz S, Becker C, Neurath MF, Reeh PW, Engel MA. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Sci Rep. 2016 Jun 30;6:28621.

Mohammad Khalil, Alexandru Babes, Roshni Lakra, Sebastian Försch, Peter W. Reeh, Stefan Wirtz, Christoph Becker, Markus F. Neurath, Matthias A. Engel. Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production. Mucosal Immunol. 2016 Mar 16.


Mueller-Tribbensee SM, Karna M, Khalil M, Neurath MF, Reeh PW, Engel MA. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One. 2015 Jul 24;10(7):e0128242. doi: 10.1371/journal.pone.0128242. eCollection 2015. PMID:26207981


Alexandru Babes, Michael J.M. Fischer, Milos Filipovic, Matthias A. Engel, Maria-Luiza Flont, Peter W. Reeh The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel. Eur J Pharmacol. 2013;24:15-22.


Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, Lewis RJ, Zimmermann K. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J. 2012;31:3795-808.
Engel MA, Khalil M, Mueller-Tribbensee SM, Becker C, Neuhuber WL, Neurath MF, Reeh PW. The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons. J Gastroenterol. 2012;47:256-65.
Engel MA, Khalil M, Siklosi N, Mueller-Tribbensee SM, Neuhuber WL, Neurath MF, Becker C, Reeh PW. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Dig Liver Dis. 2012;44:24-9.
Engel MA, Khalil M, Neurath MF. Highlights in inflammatory bowel disease – from bench to bedside. Clin Chem Lab Med. 2012;50:1229-35.


Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović-Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW. TRPA1 and Substance P Mediate Colitis in Mice. Gastroenterology. 2011;141:1346-58.
Engel MA, Becker C, Reeh PW, Neurath MF. Role of sensory neurons in colitis - increasing evidence for a neuro-immune link in the gut. Inflamm Bowel Dis. 2011;17:1030-3.
Engel MA, Izydorczyk I, Mueller-Tribbensee SM, Becker C, Neurath MF, Reeh PW. Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. Neuropeptides. 2011;45:229-37.

Ältere Publikationen

Engel MA, Neurath MF. Anticancer properties of the IL-12 family - focus on colorectal cancer. Curr Med Chem. 2010;17:3303-8.
Engel MA, Neurath MF. New pathophysiological insights and modern treatment of IBD. J Gastroenterol. 2010;45:571-83.
Marquart S, Zerr P, Akhmetshina A, Palumbo K, Reich N, Tomcik M, Horn A, Dees C, Engel MA, Zwerina J, Distler O, Schett G, Distler JH. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum. 2010;62:3467-76.

Engel MA, Rauh T, Kellermann CA, Burnat G, Hahn EG, Konturek PC. “Mice lacking CB1-, CB2-receptors or both receptors show increased susceptibility in TNBS-induced colitis”, J Physiol Pharmacol. 2010;61:89-97.
Konturek PC, Brzozowski T, Engel M, Burnat G, Gaca P, Kwiecien S, Pajdo R, Konturek SJ. Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. J Physiol Pharmacol. 2009;60:41-7.
Engel MA, Kellermann CA, Rauh T, Burnat G, Hahn EG, Konturek PC. Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide. J Physiol Pharmacol. 2008;59:673-89.
Engel MA, Raithel M, Hahn EG, Konturek PC. Eosinophilic esophagitis: new standards in diagnosis and therapy of chronic retrosternal pain. Dtsch Med Wochenschr. 2008;133:966-71.

Engel MA, Raithel M, Amann K, Greeß H, Hahn EG, Konturek PC. Rare coincidence of eosinophilic esophagitis with esophageal stenosis and intramural pseudodiverticulosis. Dig Liver Dis. 2008;40:700-6.