Our research group is interested in the interaction between commensal or pathogenic microorganisms (viruses, bacteria, parasites) and the cells of the gastrointestinal tract and the central nervous system. Particularly, we are interested in the impact of the intestinal microbiota and microbial metabolites on innate immune cells in the gut, liver, joints and CNS. We anticipate that our results will elucidate novel disease mechanisms, will help to identify novel biomarkers and therapeutic options for patients suffering from immune-mediated inflammatory diseases.
Previous Funding
2016-2020 Deutsche Forschungsgemeinschaft (DFG) SPP1656
"Impact of the intestinal microbiota and microbiota mediated immune responses on the host cell death machinery in the intestinal epithelium"
2016-2019 Interdisciplinary Center for Clinical Research (IZKF)
"Role of MLKL-dependent programmed necrotic cell death in the pathogenesis of hepatitis"
2013-2016 Deutsche Forschungsgemeinschaft (DFG) SPP 1656
“Necroptosis Regulation in Paneth Cells and its Role for Intestinal Microflora”
2013-2016 Interdisciplinary Center for Clinical Research (IZKF)
„Untersuchung zur funktionellen Rolle der cFLIP Isoformen im intestinalen Epithel“