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Funding

Research Group: MUCOSAL INFECTION BIOLOGY

Head of the Group: Prof. Dr. rer. nat. Claudia Günther

Our research group is interested in the interaction between commensal or pathogenic microorganisms (viruses, bacteria, parasites) and the cells of the gastrointestinal tract and the central nervous system. Particularly, we are interested in the impact of the intestinal microbiota and microbial metabolites on innate immune cells in the gut, liver, joints and CNS. We anticipate that our results will elucidate novel disease mechanisms, will help to identify novel biomarkers and therapeutic options for patients suffering from immune-mediated inflammatory diseases.

Funding

German Research Foundation (DFG)

Striking a moving target: From mechanisms of metastatic organ colonisation to novel systemic therapies (TRR305)

Title: Angiocrine signaling in metastatic colonization of colon cancer

German Research Foundation (DFG)

Individual Grant

Title: Gut‐Liver axis: The interrelated role of regulated necrosis as key driver of gastrointestinal and hepatic inflammation

Interdisciplinary Center for Clinical Research (IZKF)

Title: Role of extracellular vesicles as biological shuttle system for inter-kingdom communication and organ crosstalk

ELAN

Individual Grant

Title: Using self-renewing liver organoids to understand hepatobiliary organogenesis and host-microbial interaction in vitro

German Research Foundation (DFG): Research Unit: Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis (FOR2886)

Title: Intestinal epithelial cell death as modulator of intestinal dysbiosis, systemic autoimmunity and the onset of arthritis

German Research Foundation (DFG): Collaborative Research Center: “Immune-Epithelial Communication in Inflammatory Bowel Diseases (TRR241)

Title: Mechanisms linking IFN-mediated MLKL activation with intestinal inflammation

Previous Funding

2016-2020    Deutsche Forschungsgemeinschaft (DFG) SPP1656

"Impact of the intestinal microbiota and microbiota mediated immune responses on the host cell death machinery in the intestinal epithelium"

2016-2019    Interdisciplinary Center for Clinical Research (IZKF)

"Role of MLKL-dependent programmed necrotic cell death in the pathogenesis of hepatitis"

2013-2016    Deutsche Forschungsgemeinschaft (DFG) SPP 1656

“Necroptosis Regulation in Paneth Cells and its Role for Intestinal Microflora”

2013-2016    Interdisciplinary Center for Clinical Research (IZKF)

„Untersuchung zur funktionellen Rolle der cFLIP Isoformen im intestinalen Epithel“