Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Molekulare Krankheitsprozesse und neue Therapiestrategien bei kolorektalen Karzinomen und Darmentzündungen

Publikationen

2019

Schmitt H, Neufert C, Neurath MF, Atreya R. Resolution of Crohn's disease. Semin Immunopathol. 2019 Nov;41(6):737-746. doi: 10.1007/s00281-019-00756-1. Epub 2019 Sep 24. PMID: 31552470.

López-Posadas R, Fastancz P, Martínez-Sánchez LDC, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R, Carlé B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I. Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice. Gastroenterology. 2019 Nov;157(5):1293-1309. doi: 10.1053/j.gastro.2019.07.007. Epub 2019 Jul 11. PMID: 31302143.

Schulz-Kuhnt A, Zundler S, Grüneboom A, Neufert C, Wirtz S, Neurath MF, Atreya I. Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy. J Vis Exp. 2019 Apr 16;(146). doi: 10.3791/59043. PMID: 31058894.

Vitali F, Naegel A, Atreya R, Zopf S, Neufert C, Siebler J, Neurath MF, Rath T. Comparison of Hemospray® and Endoclot™ for the treatment of gastrointestinal bleeding. World J Gastroenterol. 2019 Apr 7;25(13):1592-1602. doi: 10.3748/wjg.v25.i13.1592. PMID: 30983819; PMCID: PMC6452236.

Lichnog C, Klabunde S, Becker E, Fuh F, Tripal P, Atreya R, Klenske E, Erickson R, Chiu H, Reed C, Chung S, Neufert C, Atreya I, McBride J, Neurath MF, Zundler S. Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease. Front Pharmacol. 2019 Feb 1;10:39. doi: 10.3389/fphar.2019.00039. PMID: 30774593; PMCID: PMC6367223.

Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, López-Posadas R, Lukassen S, Ekici AB, Neufert C, Atreya I, van Gisbergen KPJM, Neurath MF. Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation. Nat Immunol. 2019 Mar;20(3):288-300. doi: 10.1038/s41590-018-0298-5. Epub 2019 Jan 28. Erratum in: Nat Immunol. 2019 Apr;20(4):514. PMID: 30692620.

Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C. Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation. Gastroenterology. 2019 Mar;156(4):1082-1097.e11. doi: 10.1053/j.gastro.2018.11.029. Epub 2018 Nov 16. PMID: 30452921.

2018

Becker E, Schramm S, Binder MT, Allner C, Wiendl M, Neufert C, Atreya I, Neurath M, Zundler S. Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease. J Vis Exp. 2018 Sep 20;(139):58210. doi: 10.3791/58210. PMID: 30295649; PMCID: PMC6235239.

Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, Hirschmann S, Hildner K, Waldner MJ, Mudter J, Hartmann A, Grützmann R, Neufert C, Münster T, Neurath MF, Atreya R. Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease. Gut. 2019 May;68(5):814-828. doi: 10.1136/gutjnl-2017-315671. Epub 2018 May 30. PMID: 29848778; PMCID: PMC6580782.

Binder MT, Becker E, Wiendl M, Schleier L, Fuchs F, Leppkes M, Atreya R, Neufert C, Atreya I, Neurath MF, Zundler S. Similar Inhibition of Dynamic Adhesion of Lymphocytes From IBD Patients to MAdCAM-1 by Vedolizumab and Etrolizumab-s. Inflamm Bowel Dis. 2018 May 18;24(6):1237-1250. doi: 10.1093/ibd/izy077. PMID: 29788362.

Klenske E, Zopf S, Neufert C, Nägel A, Siebler J, Gschossmann J, Mühldorfer S, Pfeifer L, Fischer S, Vitali F, Iacucci M, Ghosh S, Rath MG, Klare P, Tontini GE, Neurath MF, Rath T. I-scan optical enhancement for the in vivo prediction of diminutive colorectal polyp histology: Results from a prospective three-phased multicentre trial. PLoS One. 2018 May 16;13(5):e0197520. doi: 10.1371/journal.pone.0197520. PMID: 29768508; PMCID: PMC5955552.

Knieling F, Gonzales Menezes J, Claussen J, Schwarz M, Neufert C, Fahlbusch FB, Rath T, Thoma OM, Kramer V, Menchicchi B, Kersten C, Scheibe K, Schürmann S, Carlé B, Rascher W, Neurath MF, Ntziachristos V, Waldner MJ. Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution. Gastroenterology. 2018 Mar;154(4):807-809.e3. doi: 10.1053/j.gastro.2017.11.285. Epub 2018 Jan 5. PMID: 29309775.

2017

Wiesinger M, Stoica D, Roessner S, Lorenz C, Fischer A, Atreya R, Neufert CF, Atreya I, Scheffold A, Schuler-Thurner B, Neurath MF, Schuler G, Voskens CJ. Good Manufacturing Practice-Compliant Production and Lot-Release of Ex VivoExpanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders. Front Immunol. 2017 Oct 26;8:1371. doi: 10.3389/fimmu.2017.01371. PMID: 29123521; PMCID: PMC5662555.

Zundler S, Klingberg A, Schillinger D, Fischer S, Neufert C, Atreya I, Gunzer M, Neurath MF. Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut. Gastroenterology. 2017 Oct;153(4):898-900. doi: 10.1053/j.gastro.2017.07.022. Epub 2017 Sep 4. PMID: 28870528.

Fuchs F, Schillinger D, Atreya R, Hirschmann S, Fischer S, Neufert C, Atreya I, Neurath MF, Zundler S. Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles. Front Immunol. 2017 Jul 3;8:764. doi: 10.3389/fimmu.2017.00764. PMID: 28717358; PMCID: PMC5495081.

Voskens CJ, Fischer A, Roessner S, Lorenz C, Hirschmann S, Atreya R, Neufert C, Atreya I, Neurath MF, Schuler G. Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative Colitis. Inflamm Bowel Dis. 2017 Aug;23(8):1348-1359. doi: 10.1097/MIB.0000000000001192. PMID: 28708802.

Knieling F, Neufert C, Hartmann A, Claussen J, Urich A, Egger C, Vetter M, Fischer S, Pfeifer L, Hagel A, Kielisch C, Görtz RS, Wildner D, Engel M, Röther J, Uter W, Siebler J, Atreya R, Rascher W, Strobel D, Neurath MF, Waldner MJ. Multispectral Optoacoustic Tomography for Assessment of Crohn's Disease Activity. N Engl J Med. 2017 Mar 30;376(13):1292-1294. doi: 10.1056/NEJMc1612455. PMID: 28355498.

Zundler S, Fischer A, Schillinger D, Binder MT, Atreya R, Rath T, Lopez-Pósadas R, Voskens CJ, Watson A, Atreya I, Neufert C, Neurath MF. The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effector T Cells In Vivo. Inflamm Bowel Dis. 2017 Mar;23(3):379-391. doi: 10.1097/MIB.0000000000001029. PMID: 28221249.

Martini E, Schneider E, Neufert C, Neurath MF, Becker C. Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β. Cell Cycle. 2016 Nov;15(21):2875-2881. doi: 10.1080/15384101.2016.1231286. Epub 2016 Oct 7. PMID: 27715398; PMCID: PMC5105921.

Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF. Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo. Gut. 2017 Nov;66(11):1936-1948. doi: 10.1136/gutjnl-2016-312439. Epub 2016 Aug 19. PMID: 27543429.

2016

Atreya I, Diall A, Dvorsky R, Atreya R, Henninger C, Grün M, Hofmann U, Schaeffeler E, López-Posadas R, Daehn I, Zenker S, Döbrönti M, Neufert C, Billmeier U, Zundler S, Fritz G, Schwab M, Neurath MF. Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases. J Crohns Colitis. 2016 Oct;10(10):1132-43. doi: 10.1093/ecco-jcc/jjw091. Epub 2016 Apr 25. PMID: 27112707.

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C. IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo. Gut. 2017 May;66(5):823-838. doi: 10.1136/gutjnl-2015-310374. Epub 2016 Jan 18. PMID: 26783184.

Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut. 2016 Oct;65(10):1642-64. doi: 10.1136/gutjnl-2015-310022. Epub 2015 Jul 24. PMID: 26209553; PMCID: PMC5036234.

2015

Benderska N, Dittrich AL, Knaup S, Rau TT, Neufert C, Wach S, Fahlbusch FB, Rauh M, Wirtz RM, Agaimy A, Srinivasan S, Mahadevan V, Rümmele P, Rapti E, Gazouli M, Hartmann A, Schneider-Stock R. miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. Inflamm Bowel Dis. 2015 Sep;21(9):2039-51. doi: 10.1097/MIB.0000000000000453. PMID: 26083618

Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut. 2015 Jul 24. pii: gutjnl-2015-310022. doi: 10.1136/gutjnl-2015-310022. [Epub ahead of print] PMID: 26209553

Steinmann S, Scheibe K, Erlenbach-Wuensch K, Neufert C, Schneider-Stock R. Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). Int J Oncol. 2015 Jul;47(1):5-15. doi: 10.3892/ijo.2015.2998. Epub 2015 May 11. Review. PMID: 25963636

Jantsch J, Schatz V, Friedrich D, Schröder A, Kopp C, Siegert I, Maronna A, Wendelborn D, Linz P, Binger KJ, Gebhardt M, Heinig M, Neubert P, Fischer F, Teufel S, David JP, Neufert C, Cavallaro A, Rakova N, Küper C, Beck FX, Neuhofer W, Muller DN, Schuler G, Uder M, Bogdan C, Luft FC, Titze J. Cutaneous na(+)
storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab. 2015 Mar 3;21(3):493-501.

2014

Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K,
Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C,
Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated
epithelial host defense during infectious colitis. J Immunol. 2014 Oct 1;193(7):3779-91.

Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, AppC, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT,Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med. 2014 Mar;20(3):313-8. doi:10.1038/nm.3462. Epub 2014 Feb 23. PubMed PMID: 24562382.

2013

Neumann H, Vieth M, Günther C, Neufert C, Kiesslich R, Grauer M, Atreya R, Neurath MF. Virtual chromoendoscopy for prediction of severity and disease extent in patients with inflammatory bowel disease: a randomized controlled study. Inflamm Bowel Dis.2013 Aug;(9):1935-42. doi:10.1097/ MIB.0b013e318290550e. PubMed PMID: 23839228.

Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest. 2013 Apr 1;123(4):1428-43. doi: 10.1172/JCI63748. Epub 2013 Mar 15. PubMed PMID: 23549083; PubMed Central PMCID: PMC3613905.

Neufert C, Agaimy A, Neurath MF, Mudter J. Confocal laser endomicroscopy for the in vivo detection of gastric foveolar metaplasia in long-standing ulcerative colitis. Inflamm Bowel Dis. 2013 Apr;19(5):E77-8. doi:10.1097/ MIB.0b013e3182813499. PubMed PMID: 23493075.

Chakilam S, Gandesiri M, Rau TT, Agaimy A, Vijayalakshmi M, Ivanovska J, Wirtz RM, Schulze-Luehrmann J, Benderska N, Wittkopf N, Chellappan A, Ruemmele P, Vieth M, Rave-Fränk M, Christiansen H, Hartmann A, Neufert CAtreya R, Becker C, Steinberg P, Schneider-Stock R. Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells. Am J Pathol. 2013 Mar;182(3):1005-20. doi: 10.1016/j.ajpath.2012.11.026. PubMed PMID: 23438478.

Foersch S, Neufert C, Neurath MF, Waldner MJ. Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. Diagn Ther Endosc. 2013;2013:250641. doi: 10.1155/2013/250641. Epub 2013 Jan 15. PubMed PMID: 23401648; PubMed Central PMCID: PMC3562574.

Ältere Publikationen

Neumann H, Neufert C, Vieth M, Siebler J, Mönkemüller K, Neurath MF.
High-definition endoscopy with i-scan enables diagnosis of characteristic mucosal lesions in Whipple's disease. Endoscopy. 2012 May;44 Suppl 2 UCTN:E217-8.

Dornhoff H, Becker C, Wirtz S, Strand D, Tenzer S, Rosfa S, Neufert C, Mudter J, Markl J, Siebler J, Neurath MF. A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling. Gastroenterology. 2012 May;142(5):1183-1194.e4.

Neufert C, Vieth M, Mönkemüller K, Neurath MF, Neumann H. In vivo diagnosis
and characterisation of Whipple's disease. Lancet Infect Dis. 2011 Dec;11(12):970.

Waldner MJ, Wirtz S, Neufert C, Becker C, Neurath MF. Confocal laser
endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice. Nat Protoc. 2011 Sep 1;6(9):1471-81.

Neufert C, Agaimy A, Wacker J, Neumann H, Neurath MF, Raithel M. Diarrhoea and massive duodenal round cell infiltration in a 27-year-old HIV positive female. Gut. 2011 Nov;60(11):1486, 1526.

Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C,
Weigmann B, Vieth M, Rose-John S, Neurath MF. VEGF receptor signaling links
inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010 Dec 20;207(13):2855-68.

Neurath MF, Wittkopf N, Wlodarski A, Waldner M, Neufert C, Wirtz S, Günther C, Becker C. Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology. 2010 Dec;139(6):1837-1843.e1.

Neufert C, Pickert G, Zheng Y, Wittkopf N, Warntjen M, Nikolaev A, Ouyang W, Neurath MF, Becker C. Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle. 2010 Feb 15;9(4):652-5. Epub 2010 Feb 12.

Paradisi A, Maisse C, Coissieux MM, Gadot N, Lépinasse F, Delloye-Bourgeois C, Delcros JG, Svrcek M, Neufert C, Fléjou JF, Scoazec JY, Mehlen P. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17146-51.

Pickert G* und Neufert C*, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA,Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009 Jul 6;206(7):1465-72. *Gleichberechtigte Erstautorschaft.

Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF.
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009 Jan;136(1):257-67.

Neufert C, Becker C, Neurath MF. An inducible mouse model of colon
carcinogenesis for the analysis of sporadic and inflammation-driven tumor
progression. Nat Protoc. 2007;2(8):1998-2004. PubMed PMID: 17703211.


Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J,
Monteleone G, Rose-John S, Neurath MF, Becker C. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol. 2007 Aug 15;179(4):2041-5.

Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007 Jul;37(7):1809-16.

Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models
of intestinal inflammation. Nat Protoc. 2007;2(3):541-6.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M,
Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007 Mar 29;446(7135):557-61.

Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006 Sep 1;177(5):2760-4.

Neufert C, Pai RK, Noss EH, Berger M, Boom WH, Harding CV. Mycobacterium
tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J Immunol. 2001 Aug 1;167(3):1542-9. PubMed PMID: 11466375.