Publikationen

Original Papers

Karsten Dafonte K, Lutz P, Jansen C, Busse M, Dietrich P, Farker K, Lipp HP, Nattermann J, Sauerbruch T, Schmiedl S, Strobach D, Trebicka J, Zocholl D, Hartmann G, Jaehde U, Coenen M. Recommendations on Drug Selection and Dose Adjustment for Patients with Liver Cirrhosis: Results from a Multidisciplinary Expert Panel. Clin Drug Investig. 2026 Apr;46(4):377-390.
doi: 10.1007/s40261-026-01536-0. Epub 2026 Mar 10.

Wormser L, Fritz V, Kappelmann-Fenzl M, Rachinger N, Escudé P, Enderle K, Kaufmann MD, Düll M, Mahli A, Zundler S, Leppkes M, Fischer S, Elsner F, Geppert CI, Hannus M, Merkel S, Erdmann M, Günther C, Evert K, El Ahmad Z, Meister G, D'Avanzo E, Stemmler MP, Neufert C, Kremer AE, Weber GF, Brabletz T, von Hörsten S, Wiest R, Schiffelers R, Hartmann A, Siebler J, Trebicka J, Waldner M, Neurath MF, Hellerbrand C, Bosserhoff AK, Dietrich P:
The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche.
Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2518418122.

Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M:
Integrin αVß6 - autoantigen and driver of epithelial remodeling in colon and bile ducts in primary sclerosing cholangitis and inflammatory bowel disease.
J Crohns Colitis. 2025 Feb 4;19(2):jjae131.

Yalcin Mutlu M, Kleyer A, Kroenke G, Fagni F, Temiz SA, Meder C, Dietrich P, Orlemann T, Mößner J, Schoenau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky ML, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G, Simon D, Tascilar K:
Paucity of viral infection symptoms in patients with immune-mediated inflammatory diseases.
BMJ Open. 2025 Jan 7;15(1):e088486.

Dorner H, Stolzer I, Mattner J, Kaminski S, Leistl S, Edrich LM, Schwendner R, Hobauer J, Sebald A, Leikam S, Gonzalez Acera M, Düll M, Lang R, Seidel G, Seitz T, Hellerbrand C, Fuhrmann G, Distler U, Tenzer S, Eichhorn P, Vieth M, Schramm C, Arnold P, Becker C, Weidinger C, Siegmund B, Atreya R, Leppkes M, Naschberger E, Sampaziotis F, Dietrich P, Rauh M, Wirtz S, Kremer AE, Neurath MF, Günther C:
Gut Pathobiont-Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease.
Gastroenterology. 2024 Nov;167(6):1183-1197.e16.

Fischer S, Donhauser M, Cohnen S, Fietkau K, Vetter M, Grübel-Liehr M, Dietrich P, Rath T, Wilfer A, Sologub L, Krebs S, Dörje F, Nagore D, Meyer S, Neurath MF, Atreya R:
Reverse switching from the biosimilar SB2 to the originator infliximab in previously switched patients with inflammatory bowel diseases: results of a prospective long-term cohort study.
Therap Adv Gastroenterol. 2024 Nov 30;17:17562848241301887.

Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R:
Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial.
Inflamm Bowel Dis. 2024 Mar 20:izae040. 

Payani E, Börner N, Kolliogiannis D, Brunner S, Klein I, Ehmer U, Denk G, Lange CM, Ograja K, Dietrich P, Werner J, Guba M:
Regional transplant rates depend more on physician-dependent variables than on proximity to transplant center.
Langenbecks Arch Surg. 2023 May 12;408(1):191.

Sommer J, Ehnis H, Seitz T, Schneider J, Wild AB, Moceri S, Buechler C, Bozec A, Weber GF, Merkel S, Beckervordersandforth R, Steinkasserer A, Schüle R, Trebicka J, Hartmann A, Bosserhoff A, von Hörsten S, Dietrich P, Hellerbrand C:
Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
Int J Mol Sci. 2023 Oct 6;24(19):14943.

Ortiz C, Klein S, Reul WH, Magdaleno F, Gröschl S, Dietrich P, Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N, Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C, Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T, Trebicka J:
Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.
Cell Rep. 2023 Feb 28;42(2):112059.

Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G: Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort.
Arthritis Rheumatol. 2022 May;74(5):783-790.

Seitz T, John N, Sommer J, Dietrich P, Thasler WE, Hartmann A, Evert K, Lang SA, Bosserhoff A, Hellerbrand C:
Role of fibroblast growth factors in the crosstalk of hepatic stellate cells and uveal melanoma cells in the liver metastatic niche.
Int. J. Mol. Sci. 2022, 23(19), 11524.

Simon D, Tascilar K, Fagni F, Kleyer A, Krönke G, Meder C, Dietrich P, Orlemann T, Mößner J, Taubmann J, Mutlu MY, Knitza J, Kemenes S, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G:
Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease:
a prospective cohort study.
Lancet Rheumatol. 2022 Sep;4(9):e614-e625.

Weindl L, Atreya I, Dietrich P, Neubeck S, Neurath MF, Pavel ME:
Targeted inhibition of the WEE1 kinase as novel therapeutic strategy in neuroendocrine neoplasms.
Endocr Relat Cancer. 2021 Jul 21;28(9):605-620.

Düll MM, Wolf K, Vetter M, Dietrich P, Neurath MF, Kremer AE:
Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus.
Front Med (Lausanne). 2021 Apr 14;8:641163.

Gaza A, Fritz V, Malek L, Wormser L, Treiber N, Danner J, Kremer AE, Thasler WE, Siebler J, Meister G, Neurath MF, Hellerbrand C, Bosserhoff AK, Dietrich P:
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
Neoplasia. 2021 May;23(5):502-514. 

Fritz V, Malek L, Gaza A, Wormser L, Appel M, Kremer AE, Thasler WE, Siebler J, Neurath MF, Hellerbrand C, Bosserhoff AK, Dietrich P:
Combined de-repression of chemoresistance associated mitogen-activated protein kinase 14 and activating transcription factor 2 by loss of microRNA-622 in hepatocellular carcinoma.
Cancers. 2021 Mar 9;13(5):1183.

Jefremow A, Wiesmueller M, Rouse RA, Dietrich P, Kremer AE, Waldner MJ, Neurath MF, Siebler J:
Beyond the border: The use of lenvatinib in advanced hepatocellular carcinoma after different treatment lines – a retrospective analysis.
J. Physiol. Pharmacol. 2020 Oct;71(5).

Seitz T, Hackl C, Freese K, Dietrich P, Mahli A, Thasler RM, Thasler WE, Lang SA, Bosserhoff AK, Hellerbrand C:
Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells.
Cancers. 2021 Jan 29;13(3):511.

Schierwagen R, Dietrich P, Klein S, Uschner FE, Ortiz C, Tyc O, Torres S, Hellerbrand C, Sauerbruch T, Trebicka J:
β-Arrestin2 is increased in liver fibrosis in humans and rodents.
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27082-27084

Simon D, Tascilar K, Krönke G, Kleyer A, Zaiss MM, Heppt F, Meder C, Atreya R, Klenske E, Dietrich P, Abdullah A, Kliem T, Corte G, Morf H, Leppkes M, Kremer AE, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Maier C, Hueber AJ, Manger K, Manger B, Berking C, Tenbusch M, Überla K, Sticherling M, Neurath MF, Schett G:
Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion.
Nat Commun. 2020 Jul 24;11(1):3774.

Dietrich P, Wormser L, Fritz V, Seitz T, De Maria M, Schambony A, Kremer AE, Günther C, Itzel T, Thasler WE, Teufel A, Trebicka J, Hartmann A, Neurath MF, von Hörsten S, Bosserhoff A, Hellerbrand C:
Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer.
J Clin Invest. 2020 May 1;130(5):2509-2526.

Seitz T, Freese K, Dietrich P, Thasler WE, Bosserhoff A, Hellerbrand C:
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma.
Sci Rep. 2020 Mar 11;10(1):4546.

Koch A, Ebert EV, Seitz T, Dietrich P, Berneburg M, Bosserhoff A, Hellerbrand C:
Characterization of glycolysis-related gene expression in malignant melanoma.
Pathol Res Pract. 2020 Jan;216(1):152752.

Freese K, Seitz T, Dietrich P, Lee SML, Thasler WE, Bosserhoff A, Hellerbrand C:
Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro.
Cancers. 2019 Oct 18;11(10).

Dietrich P, Gaza A, Wormser L, Fritz V, Hellerbrand C, Bosserhoff AK: Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Neoplasia. 2019 Mar;21(3):257-268.

Mahli A, Seitz T, Beckröge T, Freese K, Thasler WE, Benkert M, Dietrich P, Weiskirchen R, Bosserhoff A, Hellerbrand C:
Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro.
Cells. 2019 May 15;8(5).

Dietrich P, Hellerbrand C, Bosserhoff A:
The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression.
Cancers. 2019 Mar 21;11(3).

Goeppert B, Truckenmueller F, Ori A, Fritz V, Albrecht T, Fraas A, Scherer D, Silos RG, Sticht C, Gretz N, Mehrabi A, Bewerunge-Hudler M, Pusch S, Bermejo JL, Dietrich P, Schirmacher P, Renner M, Roessler S:
Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.
Sci Rep. 2019 Mar 18;9(1):4796.

Stieglitz D, Lamm S, Braig S, Feuerer L, Kuphal S, Dietrich P, Arndt S, Echtenacher B, Hellerbrand C, Karrer S, Bosserhoff AK:
BMP6-induced modulation of the tumor micro-milieu.
Oncogene. 2019 Jan;38(5):609-621.

Schmidt KM, Dietrich P, Hackl C, Guenzle J, Bronsert P, Wagner C, Fichtner-Feigl S, Schlitt HJ, Geissler EK, Hellerbrand C, Lang SA:
Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis.
Neoplasia. 2018 Dec;20(12):1198-1208.

Dietrich P, Kuphal S, Spruss T, Hellerbrand C, Bosserhoff AK:
MicroRNA-622 is a novel mediator of tumorigenicity in melanoma by targeting Kirsten rat sarcoma.
Pigment Cell Melanoma Res. 2018 Sep;31(5):614-629.

Dietrich P, Koch A, Fritz V, Hartmann A, Bosserhoff AK, Hellerbrand C:
Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance.
Gut. 2018 Jul;67(7):1328-1341.

Mahli A, Saugspier M, Koch A, Sommer J, Dietrich P, Lee S, Thasler R, Schulze-Luehrmann J, Luehrmann A, Thasler WE, Müller M, Bosserhoff A, Hellerbrand C:
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.
Gut. 2018 Apr;67(4):746-756.

Dietrich P, Kuphal S, Spruss T, Hellerbrand C, Bosserhoff AK:
Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition.
Oncogene. 2018 Feb 15;37(7):897-911.

Dietrich P, Freese K, Mahli A, Thasler WE, Hellerbrand C, Bosserhoff AK: Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option.
Oncotarget. 2017 Dec 11;9(3):3605-3618.

Delic S, Thuy A, Schulze M, Proescholdt MA, Dietrich P, Bosserhoff AK, Riemenschneider MJ:
Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority Targets.
Genes Chromosomes Cancer. 2015;54(7): 433-443.

Ruedel A*, Dietrich P* (*contributed equally), Schubert T, Hofmeister S, Hellerbrand C, Bosserhoff AK:
Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts.
Int J Clin Exp Pathol. 2015;8(5): 4953-62.

Hartl J, Dietrich P, Moleda L, Müller-Schilling M, Wiest R:
Neuropeptide Y restores non-receptor-mediated vasoconstrictive action in superior mesenteric arteries in portal hypertension.
Liver Int. 2015;35(12): 2556-63.

Dietrich P, Moleda L, Kees F, Müller M, Straub RH, Hellerbrand C, Wiest R:
Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: Impact of exogenous neuropeptide Y. 
J Hepatol. 2013 Feb;58(2):254-61.

Moleda L, Trebicka J, Dietrich P, Gäbele E, Hellerbrand C, Straub RH, Sauerbruch T, Schoelmerich J, Wiest R:
Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction.
Gut 2011; Aug;60(8):1122-32.

Review Articles, Case Reports & Commentaries

Vetter, M, Dietrich, P, Kremer, A:
Therapy adaption by dose titration of obeticholic acid in a 57-year-old female patient with PBC and advanced liver fibrosis.
SWISS MEDICAL WEEKLY (pp. 24-24). MUTTENZ: E M H SWISS MEDICAL PUBLISHERS LTD.

Linck-Paulus L, Hellerbrand C, Bosserhoff AK, Dietrich P:
Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma.
Cells. 2020 Jan 2;9(1).

Dietrich P, Bosserhoff AK:
Melanoma sponge on pigmentation gene to reduce tumour-suppressive microRNAs.
Pigment Cell Melanoma Res. 2018 May;31(3):350-351.

Dietrich P, Bosserhoff AK:
DNMT targets MiRacle torching TORCh.
Pigment Cell Melanoma Res. 2016;29(4): 399-401

Dietrich P, Bosserhoff AK:
Modifying microRNAs–another piece of the melanoma puzzle.
Pigment Cell Melanoma Res. 2015;28(5): 488-9.

Dietrich P, Hellerbrand C.
Non-alcoholic fatty liver disease, obesity and the metabolic syndrome.
Best Pract Res Clin Gastroenterol. 2014;28(4): 637-53.

Dietrich P, Hellerbrand C.
Alkoholische und nichtalkoholische Steatohepatitis – Gemeinsamkeiten und Interaktion von pathophysiologischen Mechanismen.
Verdauungskrankheiten 2012; Jahrgang 30, Nr. 5/2012, S. 233-2.