Publikationen

https://pubmed.ncbi.nlm.nih.gov/?term=Leppkes%2C+Moritz%5BAuthor%5D&sort=date

Highlights:

Müller F, Atreya R, Völkl S, Aigner M, Kretschmann S, Kharboutli S, Leppkes M, Sitte S, Strobel D, Hartmann A, Mehandru S, Colombel JF, Schett G, Mackensen A, Neurath MF. CD19 CAR T-Cell Therapy in Multidrug-Resistant Ulcerative Colitis. N Engl J Med. 2025 Sep 25;393(12):1239-1241. doi: 10.1056/NEJMc2508023. PMID: 40991907.

Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M. Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease. J Crohns Colitis. 2025 Feb 4;19(2):jjae131. doi: 10.1093/ecco-jcc/jjae131. PMID: 39212221.

Lindemann A, Roth D, Koop K, Neufert C, Zundler S, Atreya R, Neurath MF, Leppkes M. Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis. Front Med (Lausanne). 2023 Jun 9;10:1177450. doi: 10.3389/fmed.2023.1177450. PMID: 37358998; PMCID: PMC10289195.

Leppkes M, Lindemann A, Gößwein S, Paulus S, Roth D, Hartung A, Liebing E, Zundler S, Gonzalez-Acera M, Patankar JV, Mascia F, Scheibe K, Hoffmann M, Uderhardt S, Schauer C, Foersch S, Neufert C, Vieth M, Schett G, Atreya R, Kühl AA, Bleich A, Becker C, Herrmann M, Neurath MF. Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis. Gut. 2022 Dec;71(12):2414-2429. doi: 10.1136/gutjnl-2021-324725. Epub 2021 Dec 3. PMID: 34862250; PMCID: PMC9667856.

Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Stürzl M, Staats L, Mahajan A, Schauer C, Kremer AN, Völkl S, Amann K, Evert K, Falkeis C, Wehrfritz A, Rieker RJ, Hartmann A, Kremer AE, Neurath MF, Muñoz LE, Schett G, Herrmann M. Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine. 2020 Aug;58:102925. doi: 10.1016/j.ebiom.2020.102925. Epub 2020 Jul 31. PMID: 32745993; PMCID: PMC7397705.

Gößwein S, Lindemann A, Mahajan A, Maueröder C, Martini E, Patankar J, Schett G, Becker C, Wirtz S, Naumann-Bartsch N, Bianchi ME, Greer PA, Lochnit G, Herrmann M, Neurath MF, Leppkes M. Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation. Front Immunol. 2019 Oct 22;10:2481. doi: 10.3389/fimmu.2019.02481. PMID: 31695698; PMCID: PMC6817590.

Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C. Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis. Nat Commun. 2016 Mar 11;7:10973. doi:10.1038/ncomms10973. PubMed PMID: 26964500; PubMed Central PMCID: PMC4793047.

Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009 Jul 6;206(7):1465-72. doi: 10.1084/jem.20082683. PubMed PMID: 19564350;PubMed Central PMCID: PMC2715097.

Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009 Jan;136(1):257-67.doi: 10.1053/j.gastro.2008.10.018. PubMed PMID: 18992745.