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Nachwuchsarbeitsgruppe PD Dr. Rocio López Posadas, PhD

Prenylierte Proteine und Cytoskelett-Dynamik in der Darmschleimhaut


López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Wirtz S, Thonn V, Watson AJ, Brakebusch C, Bergö MO, Neurath MF, Atreya I. (2016). Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest. 126(2):611-26.

López-Posadas R, Stürzl M, Atreya I, Neurath MF, Britzen-Laurent N. Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation. Front Immunol. 2017 Oct 5;8:1240.

López-Posadas R, Neurath MF, Atreya I. Molecular pathways driving disease-specific alterations of intestinal epithelial cells. Cell Mol Life Sci. 2017 Mar;74(5):803-826.

Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut. 2016 Oct;65(10):1642-64.

López-Posadas R, Mascaraque C, González R, Suárez MD, Zarzuelo A, Martínez- Augustin O, Sánchez de Medina F. (2016). The bisphosphonate pamidronate is an intestinal antiinflammatory agent in rat and mouse experimental colitis. Inflamm Bowel Dis. 22(11):2549-2561.

Ortega-González M, Sánchez de Medina F, Molina-Santiago C, López-Posadas R, Pacheco D, Krell T, Martínez-Augustin O, Abdelali D. Fructooligosacharides reduce Pseudomonas aeruginosa PAO1 pathogenicity through distinct mechanisms. PLoS One. 2014 Jan 22;9(1):e85772.

Martínez-Moya P, Ortega-González M, González R, Anzola A, Ocón B, Hernández-Chirlaque C, López-Posadas R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F. Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats. Pharmacol Res. 2012 Aug;66(2):144-53.

López-Posadas R, Ballester I, Mascaraque C, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F. Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18). Inflamm Bowel Dis. 2011 Feb;17(2):543-56.

López-Posadas R, Requena P, González R, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O. Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis. J Nutr. 2010 Nov;140(11):2014-9.

Martínez-Augustin O, López-Posadas R, González R, Suárez MD, Zarzuelo A, Sánchez de Medina F. Genomic analysis of sulfasalazine effect in experimental colitis is consistent primarily with the modulation of NF-kappaB but not PPAR-gamma signaling. Pharmacogenet Genomics. 2009 May;19(5):363-72.

Ballester I, Daddaoua A, López-Posadas R, Nieto A, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F. The bisphosphonate alendronate improves the damage associated with trinitrobenzenesulfonic acid-induced colitis in rats. Br J Pharmacol. 2007 May;151(2):206-15.