Arbeitsgruppe Prof. Dr. med. Raja Atreya
Patientenorientierte Forschung und innovative Therapiestrategien bei chronisch entzündlichen Darmerkrankungen
Publikationen
Auswahl der wichtigsten Publikationen
Atreya R, Siegmund B. Location is important: differentiation between ileal and colonic Crohn's disease. Nat Rev Gastroenterol Hepatol,2021, Mar 12. doi: 10.1038/s41575-021-00424-6. Epub ahead of print.
Atreya R, Peyrin-Biroulet L, Klymenko A, Augustyn M, Bakulin I, Slankamenac D, Miheller P, Gasbarrini A, Hébuterne X, Arnesson K, Knittel T, Kowalski J, Neurath MF, Sandborn WJ, Reinisch W; CONDUCT study group. Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial. Lancet Gastroenterol Hepatol,2020, 5, 1063-1075.
Schmitt H, Ulmschneider J, Billmeier U, Vieth M, Scarozza P, Sonnewald S, Reid S, Atreya I, Rath T, Zundler S, Langheinrich M, Schüttler J, Hartmann A, Winkler T, Admyre C, Knittel T, Dieterich Johansson C, Zargari A, Neurath MF, Atreya R. The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis. J Crohns Colitis, 2020, 21, 508-524.
Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, Hirschmann S, Hildner K, Waldner MJ, Mudter J, Hartmann A, Grützmann R, Neufert C, Münster T, Neurath MF, Atreya R. Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease. Gut, 2019, 68, 814-828.
Atreya R, Neurath MF. Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease. Lancet Gastroenterol Hepatol, 2018, 3, 790-802.
Atreya R, Siegmund B. IBD in 2017: Development of therapy for and prediction of IBD - getting personal. Nat Rev Gastroenterol Hepatol, 2018, 15, 72-74.
Atreya R, Bloom S, Scaldaferri F, Gerardi V, Admyre C, Karlsson Å, Knittel T, Kowalski J, Lukas M, Löfberg R, Nancey S, Petryka R, Rydzewska G, Schnabel R, Seidler U, Neurath MF, Hawkey C. Clinical effects of a topically applied Toll-like receptor 9 agonist in active moderate-to-severe Ulcerative Colitis. J Crohns Colitis, 2016, 10,1294-1302.
Hess A, Roesch J, Saake M, Sergeeva M, Hirschmann S, Neumann H, Dörfler A, Neurath MF, Atreya R. Functional Brain Imaging Reveals Rapid Blockade of Abdominal Pain Response Upon Anti-TNF Therapy in Crohn's Disease. Gastroenterology, 2015, 149, 864-6.
Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, App C, Münste T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med, 2014, 20, 313-8.
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF. Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages. Gastroenterology, 2011, 141, 2026-38.
Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schürmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med, 2000, 6, 583-8.
Preise
2020 International Award, American College of Gastroenterology
2015 Rising Star Award, United European Gastroenterology Federation
2015 Paul Ehrlich- und Ludwig Darmstädter-Nachwuchspreis, Paul Ehrlich-Stiftung
2014 Theodor-Frerichs-Preis, Deutsche Gesellschaft für Innere Medizin
2009 Ludwig-Demling-Forschungspreis, Deutsche Morbus Crohn/Colitis ulcerosa Vereinigung e.V. (DCCV)
2004 Förderpreis, Boehringer Ingelheim Stiftung
2000 3. Preis der freien Vorträge, Deutsche Gesellschaft für Innere Medizin
1999 Förderungsstipendium des Fachbereichs Medizin, Johannes Gutenberg-Universität Mainz
Bücher und Buchkapitel
Atreya R.
Pouchitis.
In: Kucharzik T, Rijcken, E, Bettenworth D, Senninger N (Eds.): Therapie chronisch entzündlicher Darmerkrankungen. De Gruyter, 2018.
Atreya R, Keiner D. Chronisch entzündliche Darmerkrankungen-Krankheitsbild und Therapieoptionen.
In: Schriftenreihe der Bayerischen Landesapothekerkammer. Govi, 2017.
Atreya R, Billmeier U, Rath T, Neumann H, Neurath MF.
Binding of Membrane-Bound TNF
In: Rogler G, Herfarth H, Hibi T, Nielsen OH (Eds.): Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. Karger, 2015.
Atreya R, Neurath MF.
The normal intestinal mucosa: a state of “controlled” inflammation.
In: Targan SR, Shanahan F, Karp LC (Eds.): Inflammatory Bowel Disease: Translating Basic Science into Clinical Practice. Wiley-Blackwell, 2010.
Atreya R, Neurath MF.
The Role of the JAK/STAT Pathway in Inflammatory Bowel Diseases.
In: Stephanou A (Ed.): JAK-STAT Pathway in Disease. Landes Bioscience, 2009.
Atreya R, Neurath MF.
Future Trends in Confocal Laser Endomicroscopy: Improved Imaging Quality and Immunoendoscopy.
In: Kiesslich R, Galle PR, Neurath MF (Eds.): Atlas of Endomicroscopy. Springer Medizin Verlag Heidelberg, 2008.
Neurath MF, Becker C, Mudter J, Atreya R, Hildner K, Wirtz S, Finotto S.
New cytokines and their impact in mucosal pathogenesis.
Andus T (Ed.): Cytokines and cell homeostasis in the gastrointestinal tract. Kluwer Academic Publishers, 2000.
Neurath MF, Becker C, Mudter J, Atreya R, Hildner K, Wirtz S, Finotto S.
Immunotherapeutic approaches in inflammatory bowel diseases.
Rogler G (Ed.): IBD at the end of its first century. Kluwer Academic Publishers, 2000.