Medizin 1

Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Molekulare und immunologische Mechanismen von Erkrankungen der Leber



Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016 Nov 1;126(11):4346-4360

He GW, Günther C, Kremer AE, Thonn V, Amann K, Poremba C, Neurath MF, Wirtz S, Becker C. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 2016 Aug 26. Epub ahead of print.

Wunsch E, Krawczyk M, Milkiewicz M, Trottier J, Barbier O, Neurath MF, Lammert F, Kremer AE*, Milkiewicz P*. Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases. Sci Rep. 2016 Aug 10;6:30847. *contributed equally

Wein A, Siebler J, Goertz R, Wolff K, Ostermeier N, Busse D, Kremer AE, Koch F, Hagel A, Farnbacher M, Kammerer FJ, Neurath MF, Gruetzmann R. Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option. Case Rep Oncol. 2016 Jul 9;9(2):379-86.

Kremer AE, Mettang T. Pruritus in systemic diseases : Common and rare etiologies. Hautarzt. 2016 Aug;67(8):606-14.

Kremer AE, Kraus MR. Management of pruritus in patients with cholestatic liver disease. MMW Fortschr Med. 2016 Jun 23;158(12):64-7.

Pereira MP, Kremer AE, Mettang T, Ständer S. Chronic Pruritus in the Absence of Skin Disease: Pathophysiology, Diagnosis and Treatment. Am J Clin Dermatol. 2016 Aug;17(4):337-48.

Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun. 2016 Apr 14;7:11248.

Zopf S, Kremer AE, Neurath MF, Siebler J. Advances in hepatitis C therapy: What is the current state - what come's next? World J Hepatol. 2016 Jan 28;8(3):139-47.

Bolier R, Tolenaars D, Kremer AE, Saris J, Parés A, Verheij J, Bosma PJ, Beuers U, Oude Elferink RP. Enteroendocrine cells are a potential source of serum autotaxin in men. Biochim Biophys Acta. 2016 Apr;1862(4):696-704.

Kremer AE, Gonzales E, Schaap FG, Elferink RP, Jacquemin E, Beuers U. Serum Autotaxin Activity Correlates with Pruritus in Pediatric Cholestatic Disorders. J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):530-5.

Hegade VS, Krawczyk M, Kremer AE, Kuczka J, Gaouar F, Kuiper EM, van Buuren HR, Lammert F, Corpechot C, Jones DE. The safety and efficacy of nasobiliary drainage in the treatment of refractory cholestatic pruritus: a multicentre European study. Aliment Pharmacol Ther. 2016 Jan;43(2):294-302.

Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJ, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology. 2016 Apr;63(4):1287-98.


Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U. Pathogenesis and Management of Pruritus in PBC and PSC. Dig Dis. 2015;33 Suppl 2:164-75.

Mettang T, Ständer S, Kremer AE. Treatment of chronic itch in systemic disease: Current standards. Internist (Berl). 2015 Dec;56(12):1369-78.

Ständer S, Zeidler C, Magnolo N, Raap U, Mettang T, Kremer AE, Weisshaar E, Augustin M.Clinical management of pruritus. J Dtsch Dermatol Ges. 2015 Feb;13(2):101-15.


Nijmeijer RM, Schaap FG, Smits AJ, Kremer AE, Akkermans LM, Kroese AB, Rijkers GT, Schipper ME, Verheem A, Wijmenga C, Gooszen HG, van Erpecum KJ. Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome. PLoS One. 2014 Dec 3;9(12):e114393.

Kremer AE, Bolier R, van Dijk R, Oude Elferink RP, Beuers U. Advances in pathogenesis and management of cholestatic pruritus. Dig Dis. 2014;32(5):637-45.

Beuers U, Kremer AE, Bolier R, Oude Elferink RP. Pruritus in Cholestasis – Facts and Fiction. Hepatology. 2014 Jul;60(1):399-407.

Kremer AE, Feramisco J, Reeh PW, Beuers U, Oude Elferink RP. Receptors, cells and circuits involved in of systemic disorders. Biochim Biophys Acta. 2014 Jul;1842(7):869-92.

Nijmeijer RM, Schaap FG, Smits AJ, Kremer AE, Akkermans LM, Kroese AB, Rijkers GT, Schipper ME, Verheem A, Wijmenga C, Gooszen HG, van Erpecum KJ. Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis. PLoS One. 2014 Dec 3;9(12):e114393. doi: 10.1371/journal.pone.0114393. eCollection 2014. PMID: 25470824


Huesmann M, Huesmann T, Osada N, Phan NQ, Kremer AE, Ständer S.Cholestatic Pruritus: a retrospective analysis on clinical characteristics and treatment response. J Deutsch Dermatol Ges. 2013;11(2):158-68.

Schaap FG, Kremer AE, Lamers WH, Jansen PL, Gaemers IC. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie. 2013 Apr;95(4):692-9.


Lisboa LF, Asthana S, Kremer A, Swain M, Bagshaw SM, Gibney N, Karvellas CJ. Blood cytokine, chemokine and gene expression in cholestasis patients with intractable pruritis treated with a molecular adsorbent recirculating system: a case series. Can J Gastroenterol. 2012 Nov;26(11):799-805.

Kremer AE, Oude Elferink RP, Beuers U. Cholestatic pruritus: New insights into pathophysiology and current treatment. Hautarzt. 2012 Jul;63(7):532-8.

Szegedi K, Kremer AE, Kezic S, Teunissen MB, Bos JD, Luiten RM, Res PC, Middelkamp-Hup MA. Increased frequencies of IL-31-producing T cells are found in skin of chronic atopic dermatitis skin. Exp Dermatol. 2012 Jun;21(6):431-6.

Kremer AE, Dijk RV, Leckie P, Schaap FG, Kuiper EM, Mettang T, Reiners KS, Raap U, Buuren HR, Erpecum KJ, Davies NA, Rust C, Engert A, Jalan R, Elferink RP, Beuers U. Autotaxin is elevated in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions.
Hepatology 2012 Oct;56(4):1391-400.

Mustafa DA, Dekker LJ, Stingl C, Kremer A, Stoop M, Sillevis Smitt PA, Kros JM, Luider TM. A proteome comparison between physiological angiogenesis and angiogenesis in glioblastoma. Mol Cell Proteomics. 2012 Jun;11(6):M111.008466. doi: 10.1074/mcp.M111.008466. Epub 2012 Jan 25. PMID: 22278369

Kremer AE, Beuers U. Brushing of bile duct stenoses for the true dignity. Liver Int. 2012 May;32(5):698 700.


Oude Elferink RP, Kremer AE, Beuers U.Mediators of pruritus during cholestasis. Curr Opin Gastroenterol. 2011 May;27(3):289-93.

Kremer AE, Oude Elferink RP, Beuers U. Pathophysiology and current management of pruritus in liver disease. Clin Res Hepatol Gastroenterol. 2011 Feb;35(2):89-97.

Oude Elferink RP, Kremer AE, Martens JJ, Beuers U. The molecular mechanism of cholestatic pruritus. Dig Dis. 2011;29(1):66-71.

Kremer AE, Maillette de Buy Wenniger L, Oude Elferink RP, Beuers U. Pruritus in liver disease. Pathogenesis and treatment. Ned Tijdschr Geneeskd. 2011;155(52):A4045.

Ältere Publikationen

Beuers U, Hohenester S, de Buy Wenniger LJ, Kremer AE, Jansen PL, Oude Elferink RP.
The biliary HCO3- umbrella. A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 2010 Oct; 52(4):1489-96.

Kremer AE, Martens JJ, Kulik W, Ruëff F, Kuiper EM, Buuren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Oude Elferink RP. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 2010 Sep; 139(3):1008-18.

Kremer AE, Rust C, Eichhorn P, Beuers U, Holdenrieder S. Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers. Expert Rev Mol Diagn. 2009 Mar; 9(2):139-56.

Kremer AE, Beuers U, Oude Elferink RP, Pusl T. Pathogenesis and treatment of cholestatic pruritus. Drugs. 2008;68(15):2163-82.

Holdenrieder S, Nagel D, Schalhorn A, Heinemann V, Wilkowski R, von Pawel J, Raith H, Feldmann K, Kremer AE, Müller S, Geiger S, Hamann GF, Seidel D, Stieber P. Clinical relevance of circulating nucleosomes in cancer disease. Ann N Y Acad Sci. 2008 Aug; 1137:180-9.

Kremer AE, Budenhofer U, Beuers U, Rust C. A 47-Year-Old Dog Breeder with Chronic Polyarthritis, Weight Loss and High Fever. Z Gastroenterol. 2008 May; 46(5):431-4.

Kremer A, Holdenrieder S, Stieber P, Wilkowski R, Nagel D, Seidel D. Nucleosomes in colorectal cancer patients during radiochemotherapy.Tumor Biol 2006; 27: 235-242.

Holdenrieder S, Stieber P, Chan LYS, Geiger S, Kremer A, Nagel D, Lo YMD. Cell-free DNA in serum and plasma: comparison of ELISA and quantitative PCR. Clin Chem 2005; 51: 1544-46.

Kremer A, Wilkowski R, Holdenrieder S, Nagel D, Stieber P, Seidel D. Nucleosomes in pancreatic cancer patients during radiochemotherapy. Tumor Biol 2005; 26:44-49.

Books and Bookchapters

Kremer AE & Weisshaar E. Endocrine diseases. pp. 267-270. In: Pruritus. Laurent Misery and Sonja Ständer (Eds), Springer, London, 2nd Edition, 2016. ISBN 978-3-319-33140-9

Pirschel W. & Kremer AE. Hepatobiliary diseases. pp. 253-265. In: Pruritus. Laurent Misery and Sonja Ständer (Eds), Springer, London, 2nd Edition, 2016. ISBN 978-3-319-33140-9

Kremer AE, Oude Elferink RP, Beuers U: Pruritus in patients with hepatobiliary diseases. pp. 177-187. In: Pruritus. Laurent Misery and Sonja Ständer (Eds), Springer, London, 1st Edition, 2010.
ISBN 978-1-84882-322-8

Kremer A. Crashkurs Biochemie, Urban & Fischer-Verlag, Elsevier Group, Berlin, 1st Edition, 2005.
ISBN 978-3-43743-500-3

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