Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Mukosale Entzündung und Tumorentstehung: Optische Bildgebung und molekulare Pathogenese

Publikationen

2016

Mlecnik B, Bindea G, Kirilovsky A, Angell HK, Obenauf AC, Tosolini M, Church SE, Maby P, Vasaturo A, Angelova M, Fredriksen T, Mauger S, Waldner M, Berger A, Speicher MR, Pagès F, Valge-Archer V, Galon J. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci Transl Med. 2016 Feb 24;8(327):327ra26. doi: 10.1126/scitranslmed.aad6352. PMID: 26912905

2015

Haep L, Britzen-Laurent N, Weber TG, Naschberger E, Schaefer A, Kremmer E, Foersch S, Vieth M, Scheuer W, Wirtz S, Waldner M, Stürzl M. Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice. Inflamm Bowel Dis. 2015 Oct;2 (10):2360-71. doi: 10.1097/MIB.0000000000000490. PMID: 26164664

Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ. VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis. Gastroenterology. 2015 Jul;149(1):177-189.e10. doi: 10.1053/j.gastro.2015.03.016. Epub 2015 Mar 19. PMID: 25797700

Rath T, Billmeier U, Waldner MJ, Atreya R, Neurath MF. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Arch Toxicol. 2015 Apr;89(4):541-54. doi: 10.1007/s00204-015-1461-5. Epub 2015 Jan 30. Review. PMID: 25632846

Angelova M, Charoentong P, Hackl H, Fischer ML, Snajder R, Krogsdam AM, Waldner MJ, Bindea G, Mlecnik B, Galon J, Trajanoski Z. Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Genome Biol. 2015 Mar 31;16:64. doi: 10.1186/s13059-015-0620 PMID:25853550

Steiner S, Daniel C, Fischer A, Atreya I, Hirschmann S, Waldner M, Neumann H, Neurath M, Atreya R, Weigmann B. Cyclosporine A regulates pro-inflammatory cytokine production in ulcerative colitis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):53-63. doi: 10.1007/s00005-014-0309-7. Epub 2014 Aug 26. PMID: 25155925

Meinhardt K, Kroeger I, Bauer R, Ganss F, Ovsiy I, Rothamer J, Büttner M, Atreya I, Waldner M, Bittrich M, Lehmann CH, Rieger MA, Beilhack A, Zeiser R, Edinger M, Dudziak D, Mackensen A, Rehli M, Ullrich E. Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host-effects. Oncoimmunology. 2015 Feb 3;4(1):e981483. eCollection 2015 Jan. PMID: 25949862

2014

Atreya, R., Neumann, H., Neufert, C., Waldner, M.J., Billmeier, U., Zopf, Y., … Neurath, M. F. (2014). In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease. Nat Med, 20(3), 313–8. doi:10.1038/nm.3462

Steiner, S., Daniel, C., Fischer, A., Atreya, I., Hirschmann, S., Waldner, M., … Weigmann, B. (2014). Cyclosporine A Regulates Pro-Inflammatory Cytokine Production in Ulcerative Colitis. Arch Immunol Ther Ex. doi:10.1007/s00005-014-0309-7

Zenker, S., Panteleev-Ivlev, J., Wirtz, S., Kishimoto, T., Waldner, M.J., Ksionda, O., … Atreya, I. (2014). A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6. J Immunol, 192(6), 2830–6. doi:10.4049/jimmunol.1300157

Backert, I., Koralov, S. B., Wirtz, S., Kitowski, V., Billmeier, U., Martini, E., Hofmann, K., Hildner, K., Wittkopf, N., Brecht, K., Waldner, M., Rajewsky, K., Neurath, M.F., Neufert, C. (2014). STAT3 Activation in Th17 and Th22 Cells Controls IL-22-Mediated Epithelial Host Defense during Infectious Colitis.  J Immunol. doi:10.4049/jimmunol.1303076

Karbach, S., Croxford, A. L., Oelze, M., Schüler, R., Minwegen, D., Wegner-Kops, J., Koukes, L., Yogev, N., Nikolaev, A., Reißig, S., Ullmann, A., Knorr, M., Waldner, M., … Münzel, T. (2014). Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease.  Arterioscl Throm Vas. doi:10.1161/ATVBAHA.114.304108

Mlecnik, B., Bindea, G., Angell, H. K., Sasso, M. S., Obenauf, A. C., Angell, H., Fredriksen, T., Lafontaine, L., Berger, A., Waldner, M. Galon, J. (2014). Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci Transl Med, 6(228), 228ra37. doi:10.1126/scitranslmed.3007240

2013

Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M., Obenauf, A. C., … Galon, J. (2013). Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity, 39(4), 782–95. doi:10.1016/j.immuni.2013.10.003

Britzen-Laurent, N., Lipnik, K., Ocker, M., Naschberger, E., Schellerer, V. S., Croner, R. S., Vieth, M., Waldner, M., Stürzl, M. (2013). GBP-1 acts as a tumor suppressor in colorectal cancer cells. Carcinogenesis, 34(1), 153–62. doi:10.1093/carcin/bgs310

Foersch, S., Neufert, C., Neurath, M. F., & Waldner, M.J. (2013). Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. Diagnostic and Therapeutic Endoscopy, 2013, 250641. doi:10.1155/2013/250641

McHedlidze, T., Waldner, M., Zopf, S., Walker, J., Rankin, A. L., Schuchmann, M., … Wirtz, S. (2013). Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 39(2), 357–71. doi:10.1016/j.immuni.2013.07.018

Neufert, C., Becker, C., Türeci, Ö., Waldner, M.J., Backert, I., Floh, K.,  Neurath, M. F. (2013). Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest, 123(4), 1428–43. doi:10.1172/JCI63748

Pickert, G., Lim, H.-Y., Weigert, A., Häussler, A., Myrczek, T., Waldner, M., Tegeder, I. (2013). Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. International Journal of Cancer. Int J Cancer, 132(3), 591–604. doi:10.1002/ijc.27706

Schürmann, S., Foersch, S., Atreya, R., Neumann, H., Friedrich, O., Neurath, M. F., & Waldner, M.J. (2013). Label-free imaging of inflammatory bowel disease using multiphoton microscopy. Gastroenterology, 145(3), 514–6. doi:10.1053/j.gastro.2013.06.054

2012

Waldner, M.J., Baethmann, A., Uhl, E., & Lehmberg, J. (2012). Bradykinin-induced leukocyte- and platelet-endothelium interactions in the cerebral microcirculation. Brain Res, 1448, 163–9. doi:10.1016/j.brainres.2012.02.010

Wittkopf, N., Günther, C., Martini, E., Waldner, M., Amann, K. U., Neurath, M. F., & Becker, C. (2012). Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut. Clin Dev Immunol, 2012, 278059. doi:10.1155/2012/278059

Goertz, R. S., Heide, R., Bernatik, T., Waldner, M.J., Mudter, J., Neurath, M. F., & Strobel, D. (2012). Mesenteric transit time using contrast-enhanced ultrasound (CEUS) does not correlate with disease activity in Crohn’s disease. Ultraschall Med, 33(2), 164–9. doi:10.1055/s-0031-1282064

Knieling, F.*, Waldner, M.J.*, Goertz, R. S., & Strobel, D. (2012). Quantification of dynamic contrast-enhanced ultrasound in HCC: prediction of response to a new combination therapy of sorafenib and panobinostat in advanced hepatocellular carcinoma. BMJ Case Reports, 2012. doi:10.1136/bcr-2012-007576
* Contributed equally

Ältere Publikationen

Günther, C., Martini, E., Wittkopf, N., Amann, K., Weigmann, B., Neumann, H., Waldner, M. Becker, C. (2011). Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature, 477(7364), 335–9. doi:10.1038/nature10400

Atreya, R., Zimmer, M., Bartsch, B., Waldner, M.J., Atreya, I., Neumann, H., … Neurath, M. F. (2011). Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14+ macrophages. Gastroenterology, 141(6), 2026–38. doi:10.1053/j.gastro.2011.08.032

Waldner, M.J., Wirtz, S., Neufert, C., Becker, C., & Neurath, M. F. (2011). Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice. Nat Protoc, 6(9), 1471–81. doi:10.1038/nprot.2011.377

Foersch, S., Kiesslich, R., Waldner, M.J., Delaney, P., Galle, P. R., Neurath, M. F., & Goetz, M. (2010). Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy. Gut, 59(8), 1046–55. doi:10.1136/gut.2009.202986

Goetz, M., Ziebart, A., Foersch, S., Vieth, M., Waldner, M.J., Delaney, P., … Kiesslich, R. (2010). In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor. Gastroenterology, 138(2), 435–46. doi:10.1053/j.gastro.2009.10.032

Neurath, M. F., Wittkopf, N., Wlodarski, A., Waldner, M., Neufert, C., Wirtz, S., … Becker, C. (2010). Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology, 139(6), 1837–1843.e1. doi:10.1053/j.gastro.2010.10.007

Waldner, M.J., Wirtz, S., Jefremow, A., Warntjen, M., Neufert, C., Atreya, R., … Neurath, M. F. (2010). VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med, 207(13), 2855–68. doi:10.1084/jem.20100438

Waldner, M.J., Wirtz, S., Becker, C., Seidel, D., Tubbe, I., Cappel, K., … Neurath, M. F. (2010). Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer. Inflamm Bowel Dis, 16(4), 559–67. doi:10.1002/ibd.21107

Lehmberg, J., Waldner, M., Baethmann, A., & Uhl, E. (2008). Inflammatory response to nitrous oxide in the central nervous system. Brain Res, 1246, 88–95. doi:10.1016/j.brainres.2008.09.064

Waldner, M., Hutter, J., Uhl, E., Baethmann, A., & Lehmberg, J. (2007). Modified labeling technique for in vivo visualization of platelets in the cerebral microcirculation of Mongolian gerbils. J Cerebr Blood F Met, 27(2), 327–33. doi:10.1038/sj.jcbfm.9600341

Übersichtsarbeiten

Waldner, M.J., & Neurath, M. F. (2014). Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. Semin Immunol, 26(1), 75–9. doi:10.1016/j.smim.2013.12.003

Foersch, S., Waldner, M.J., & Neurath, M. F. (2013). Innate and adaptive immunity in inflammatory bowel diseases. Digest Dis, 31(3-4), 317–20. doi:10.1159/000354685

Waldner, M.J., Foersch, S., & Neurath, M. F. (2012). Interleukin-6--a key regulator of colorectal cancer development. Int J Biol Sci, 8(9), 1248–53. doi:10.7150/ijbs.4614

Waldner, M.J., & Neurath, M. F. (2012). Potential avenues for immunotherapy of colitis-associated neoplasia. Immunotherapy, 4(4), 397–405. doi:10.2217/imt.12.15

Foersch, S., Waldner, M.J., & Neurath, M. F. (2012). Colitis and colorectal cancer.  Digest Dis, 30(5), 469–76. doi:10.1159/000341692

Waldner, M.J., & Neurath, M. F. (2012). Targeting the VEGF signaling pathway in cancer therapy.  Expert Opin Ther Tar, 16(1), 5–13. doi:10.1517/14728222.2011.641951

Atreya, R., Waldner, M.J., & Neurath, M. F. (2010). Molecular imaging: interaction between basic and clinical science.  Gastroenterol Clin N, 39(4), 911–22. doi:10.1016/j.gtc.2010.08.025

Waldner, M.J., & Neurath, M. F. (2010). The molecular therapy of colorectal cancer.  Mol Aspects Med, 31(2), 171–8. doi:10.1016/j.mam.2010.02.005

Waldner, M.J., & Neurath, M. F. (2009). Colitis-associated cancer: the role of T cells in tumor development. Semin Immunopathol, 31(2), 249–56. doi:10.1007/s00281-009-0161-8

Waldner, M.J., & Neurath, M. F. (2009). Gene therapy using IL 12 family members in infection, auto immunity, and cancer.  Curr Gene Ther, 9(4), 239–47. doi:10.2174/156652309788921099

Waldner, M.J., & Neurath, M. F. (2009). Novel cytokine-targeted therapies and intestinal inflammation.  Curr Opin Pharmacol, 9(6), 702–7. doi:10.1016/j.coph.2009.07.005

Waldner, M.J., & Neurath, M. F. (2008). Cytokines in colitis associated cancer: potential drug targets?  Inflamm Allergy Drug Targets, 7(3), 187–94. doi:10.2174/187152808785748137

Waldner, M., Schimanski, C.-C., & Neurath, M.-F. (2006). Colon cancer and the immune system: the role of tumor invading T cells.  World J Gastroentero, 12(45), 7233–8.

 
 
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