Zum Hauptinhalt springen

Publikationen

Arbeitsgruppe Prof. Dr. rer. nat. Christoph Becker

Immunregulation der Epithelzellbarriere im Darm

Jahresberichte

2023

Chiriac M.T., Z. Hracsko, C. Becker, M.F. Neurath. STAT2 controls colorectal tumorigenesis and resistance to anti-cancer drugs. Cancers. 2023. 15(22):5423.

Plattner C., G. Lamberti, P. Blattmann, A. Kirchmair, D. Rieder, Z. Loncova, G. Sturm, S. Scheidl, M. Ijsselsteijn, G. Fotakis, A. Noureen, R. Lisandrelli, N. Böck, N. Nemati, A. Krogsdam, S. Daum, F. Finotello, A. Somarakis, A. Schäfer, D. Wilflingseder, M. Gonzalez Acera, D. Öfner, L.A. Huber, H. Clevers, C. Becker, H.F. Farin, F.R. Greten, R. Aebersold, N. Filipe da Cunha Carvalho de Miranda, Z. Trajanoski. Functional and Spatial Proteomics Profiling Reveals Intra- and Intercellular Signaling Crosstalk in Colorectal Cancer. iScience. 2023. 26(12):108399.

Chiriac M.T., Z. Hracsko, C. Günther, M. Gonzalez-Acera, R. Atreya, I. Stolzer, L. Wittner, A. Dressel, L. Schickedanz, R. Gamez-Belmonte, G. Hundorfean, S. Zundler, T. Rath, S. Vetrano, S. Danese, G. Sturm, Z. Trajanoski, A.A. Kühl, B. Siegmund, A. Hartmann, S. Wirtz, J. Siebler, S. Finotto, C. Becker, M.F. Neurath. The cytokine IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Gut. 2023.  Oct 26:gutjnl-2023-329628. doi: 10.1136/gutjnl-2023-329628. Online ahead of print.

Wiese J.J., S. Manna, A.A. Kühl, A. Fascì, S. Elezkurtaj, E. Sonnenberg, M. Bubeck, R. Atreya, C. Becker, B. Weixler, B. Siegmund, J.V. Patankar, M.S. Prüß, M. Schumann. Myenteric plexus immune cell infiltrations and neurotransmitter expression in Crohn’s disease and ulcerative colitis. Journal of Crohn's and Colitis. 2023. Aug 11:jjad122. doi: 10.1093/ecco-jcc/jjad122. Online ahead of print.

Iyer K, L. Erkert, C. Becker. Know your neighbors: Microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease. Frontiers Cell Developmental Biol. 2023. 11:1228283. doi: 10.3389/fcell.2023.1228283. eCollection 2023.

Naschberger E., C. Flierl, J. Huang, L. Erkert, R. Gamez-Belmonte, M. Gonzalez-Acera, M. Bober, M. Mehnert, C. Becker, V.S. Schellerer, N. Britzen-Laurent, M. Stürzl. Analysis of the interferon-gamma induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD. Frontiers Cell Developmental Biol. 11:1213383. doi: 10.3389/fcell.2023.1213383. eCollection 2023.

Dietschmann A, A. Ruhl, P.J. Murray, C. Günther, C. Becker, P. Fallon, D. Voehringer. Th2-dependent disappearance and trans-differentiation of alveolar macrophages. European Journal of Immunol. 2023. Jul 15:e2350475. doi: 10.1002/eji.202350475. Online ahead of print.

Gámez-Belmonte R., M. Mahapatro, M. Gonzalez-Acera, E. Naschberger, Y. Yu, M. Tena-Garitaonaindia, J.V. Patankar, Y. Wagner, E. Podstawa, L. Schödel, M. Bubeck, M.F. Neurath, M. Stürzl, C. Becker. Epithelial Presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling. Gut. 2023. 72(6):1155-1166.

Patankar J.V., M. Bubeck, M. Gonzalez Acera, C. Becker. Breaking Bad: Necroptosis in the pathogenesis of gastrointestinal diseases. Frontiers Immunol. 2023. 14:1203903. doi: 10.3389/fimmu.2023.1203903. eCollection 2023.

Vitale I., F. Pietrocola, E. Guilbaud,... C. Becker… M. Piacentini, G. Kroemer, L. Galluzzi. Apoptotic cell death in disease – Current understanding of the NCCD 2023. Cell Death & Differentiation. 2023.  30(5):1097-1154.

Wittner L., L. Wagener, J.J. Wiese, I. Stolzer, S.M. Krug, E. Naschberger, R. Jackstadt, R. Beyaert, R. Atreya, A.A. Kühl, G. Sturm, M. González-Acera, J.V. Patankar, C. Becker, B. Siegmund, Z. Trajanoski, B. Winner, M.F. Neurath, M. Schumann, C. Günther. Proteolytic activity of the paracaspase MALT1 is involved in epithelial restitution and mucosal healing. Int. J. Mol. Sci. 2023, 24(8), 7402

Krug J, G. Rodrian, K. Petter, H. Yang, S. Khoziainova, W. Guo, A. Bénard, S. Merkel, S. Gellert, S. Maschauer, M. Spermann, M. Waldner, P. Bailey, C. Pilarsky, A. Liebl, P. Tripal, J. Christoph, E. Naschberger, R. Croner, V.S. Schellerer, C. Becker, A. Hartmann, T. Tüting, O. Prante, R. Grützmann, S.I. Grivennikov, M. Stürzl, N. Britzen-Laurent. N-glycosylation regulates intrinsic IFN-γ resistance in colorectal cancer: implications for immunotherapy. Gastroenterology. 2023. 164(3):392-406.e5.

Becker C., T.E. Adolph. Disentangling tryptophan metabolism in inflammatory bowel diseases. Gut. 2023. Jan 3:gutjnl-2022-328853. doi: 10.1136/gutjnl-2022-328853. Online ahead of print


2022

Yu Y., R. Gamez-Belmonte, J. Patankar, E. Liebing, C. Becker. The role of programmed necrosis in colorectal cancer. Cancers (Basel). 2022. 14(17):4295.

Schmalzl A., L. Kreiss, M. Waldner, S. Schürmann, M.F. Neurath, C. Becker and S. Wirtz. Interferon regulatory factor 1 (IRF-1) drives intestinal group 3 innate lymphoid responses during Citrobacter rodentium infections. Nat Commun. 2022. 13(1):5730

Denk D., V. Petrocelli, C. Conche, M. Drachsler, P.K. Ziegler, A. Braun, A. Kress, A.M. Nicolas, K. Mohs, C. Becker, M.F. Neurath, H.F. Farin, C.J. Buchholz, P.A. Andreux, C. Rinsch and F.R. Greten.  Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022. 55(11):2059-2073.e8.

Hohmann M., I. Ganzleben, A. Grünberg, J. Gonzales-Menezes, F. Klämpfl, B. Lengenfelder, E. Liebing, C. Heichler, C. Neufert, C. Becker, M.F. Neurath, M.J. Waldner, M. Schmidt. In vivo multi spectral colonoscopy in mice. Sci Rep. 2022. 12(1):8753.

Kreiß L., I. Ganzleben, A. Mühlberg, P. Ritter, D. Schneidereit, C. Becker, M.F. Neurath, O. Friedrich, S. Schürmann, M. Waldner. Label-free analysis of inflammatory tissue remodeling in murine lung tissue based on multiphoton microscopy, Raman spectroscopy and machine learning. J Biophotonics. 2022. 15(9):e202200073.

Yu Y., A. Herrmann, V. Thonn, A. Cordsmeier, M.F. Neurath, A. Ensser, C. Becker. SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells. Cells. 2022. 11(8), 1262.

Tisch N., C. Mogler, A. Stojanovic, R. Luck, E.A. Korhonen, A. Ellerkmann, H. Adler, M. Singhal, G. Schermann, L. Erkert, J.V. Patankar, A. Karakatsani, A.L. Scherr, Y. Fuchs, A. Cerwenka, S. Wirtz, B.C. Köhler, H.G. Augustin, C. Becker, T. Schmidt, C. Ruiz de Almodóvar. Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice.  EMBO Molecular Medicine. 2022. e14121.

Martínez-Sánchez, L.D.C., P.A. Ngo, R. Pradhan, L.S. Becker, D. Böhringer, D. Soteriou, M. Kubankova, C. Schweitzer, T. Koch, V. Thonn, L. Erkert, I. Stolzer, C. Günther, C. Becker, B. Weigmann, M. Klewer, C. Daniel, K. Amann, S. Tenzer, R. Atreya, M.O. Bergo, C.H. Brakebusch, A.J.M. Watson, J. Guck, B. Fabry, I. Atreya, M.F. Neurath, R. López-Posadas. Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation. Gut. 2022 Mar 3;gutjnl-2021-325520. doi: 10.1136/gutjnl-2021-325520. Online ahead of print.

Yu Y., V. Thonn, J.V. Patankar, O.-M. Thoma, M. Zielinska, L. Bao, M. Gonzalez Acera, S. Wallmüller, F.B. Engel, M. Stürzl, M.F. Neurath, E. Liebing, C. Becker. SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth. Cell Death and Disease. 2022. 13(1):52

Stehr A.M., G. Wang, R. Demmler, M.P. Stemmler, J. Straube, P. Tripal, B. Schmid, C.I. Geppert, A. Hartmann, L.E. Muñoz, J. Schoen, S. Völkl, S. Merkel, C. Becker, G. Schett, R. Grützmann, E. Naschberger, M. Herrmann, Michael Stürzl. Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer. J Pathol. 2022. 256(4):455-467.


2021

Patankar J.V., F. Mascia, S. Kantham, M. Mahapatro, C. Heichler, K. Scheibe, M.J. Mathew, L. Schödel, B. Ruder, M. Gonzalez Acera, W. Li, Y. Yu, M. Leppkes, M.F. Neurath, S. Wirtz, C. Neufert, R. Atreya, R.N. Young, C. Becker.  E-type prostanoid receptor 4 promotes resolution of colitis by blocking intestinal epithelial necroptosis. Nature Cell Biol. 2021. 23(7):796-807.

Gonzalez Acera M., M. Bubeck, F. Mascia, L. Diemand, G. Sturm, A.A. Kühl, R. Atreya, D.C. Lie, M.F. Neurath, M. Schumann, C.S.N. Klose, Z. Trajanoski, C. Becker, J.V. Patankar. Dynamic, transient and robust increase in the innervation of the inflamed mucosa in inflammatory bowel disease. Cells. 2021. 10, 2253.

Gonzalez Acera M., J.V. Patankar, L. Diemand, M.F. Neurath, S. Wirtz, C. Becker. Comparative transcriptomics of IBD patients indicates induction of type 2 immunity irrespective of the disease ideotype. Frontiers in Medicine. 2021. 8:664045.

Lang-Schwarz C, Angeloni M, Agaimy A, Atreya R, Becker C, Dregelies T, Danese S, Fléjou JF, Gaßler N, Grabsch HI, Hartmann A, Kamarádová K, Kühl AA, Lauwers GY, Lugli A, Nagtegaal I, Neurath MF, Oberhuber G, Peyrin-Biroulet L, Rath T, Riddell R, Rubio CA, Sheahan K, Siegmund B, Tilg H, Villanacci V, Westerhoff M, Ferrazzi F, Vieth M. Validation of the "Inflammatory Bowel Disease - Distribution, Chronicity, Activity (IBD-DCA) Score" for Ulcerative Colitis and Crohn´s disease. J Crohns Colitis. 2021. Mar 27:jjab055. doi: 10.1093/ecco-jcc/jjab055. Online ahead of print.

Kang L, Schmalzl A, Leupold T, Gonzalez-Acera M, Atreya R, Neurath MF, Becker C, Wirtz S. CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. Front Immunol. 2021. 11:609400.

Mahapatro M., L. Erkert, C. Becker. Cytokine mediated crosstalk between immune cells and epithelial cells in the gut. Cells. 2021. 10(1):E111.

Regensburger D, Tenkerian C, Pürzer V, Schmid B, Wohlfahrt T, Stolzer I, López-Posadas R, Günther C, Waldner MJ, Becker C, Sticht H, Petter K, Flierl C, Gass T, Thoenissen T, Geppert CI, Britzen-Laurent N, Méniel VS, Ramming A, Stürzl M, Naschberger E. Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2021. 27(9):1491-1502.

Ganzleben I., M.F. Neurath, C. Becker. Autophagy in cancer therapy – Molecular mechanisms and current clinical advances. Cancers (Basel). 2021. 13(21), 5575

Lang-Schwarz C, Agaimy A, Atreya R, Becker C, Danese S, Fléjou JF, Gaßler N, Grabsch HI, Hartmann A, Kamarádová K, Kühl AA, Lauwers GY, Lugli A, Nagtegaal I, Neurath MF, Oberhuber G, Peyrin-Biroulet L, Rath T, Riddell R, Rubio CA, Sheahan K, Tilg H, Villanacci V, Westerhoff M, Vieth M. Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn's disease.
Virchows Arch. 2021. 478(3):581-594.

Patankar JV, Chiriac MT, Lehmann M, Kühl AA, Atreya R and Becker C. The SARS-CoV-2 attachment receptor ACE2 is decreased in Crohn's disease and regulated by microbial and inflammatory signaling.  Gastroenterology. 2021. 60(3):925-928.e4.


2020

Gamez-Belmonte R, L. Erkert, S. Wirtz, C. Becker. The regulation of intestinal inflammation and cancer development by type 2 immune responses.  Int. J. Mol. Sci. 2020, 21(24), 9772

Zielińska M, Szymaszkiewicz A, Jacenik D, Schodel L, Sałaga M, Zatorski H, Kordek R, Becker C, Krajewska WM, Fichna J. Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice. Eur J Pharmacol. 2020. 885:173463.

Ruder B. and C. Becker. At the forefront of the mucosal barrier: The role of macrophages in the intestine. 2020. Cells. 9(10):E2162.

Ganzleben I., M. Hohmann, A. Grünberg, J. Gonzales-Menezes, M. Vieth, E. Liebing, C. Günther, V. Thonn, D. Beß, C. Becker, M. Schmidt, M.F. Neurath, M.J. Waldner. Topical application of Chlorin e6-PVP (Ce6-PVP) for improved endoscopic detection of neoplastic lesions in a murine colitis-associated cancer model.  Sci Rep. 2020.  10(1):13129

Patankar JV, C. Becker. Cell death in the gut epithelium and implications for chronic inflammation. Nature Reviews Gastroenterol Hepatol. 2020. 17(9):543-556.

Yu Y.Q., M. Zielinska, W. Li, D.B. Bernkopf, C.S. Heilingloh, M.F. Neurath, C. Becker. PGAM5-MAVS interaction regulates TBK1/ IRF3 dependent antiviral responses. Sci Rep. 2020. 10(1):8323.

Pickert G., S. Wirtz, J. Matzner, M. Ashfaq-Khan, R. Heck, S. Rosigkeit, D. Thies, R. Surabattula, D. Ehmann, J. Wehkamp, M. Aslam, G. He, A. Weigert, F. Foerster, L. Klotz, J.S. Frick, C. Becker, E. Bockamp, D. Schuppan. Wheat consumption aggravates colitis in mice via amylase trypsin inhibitor-mediated dysbiosis. Gastroenterology. 2020. 159(1):257-272

Mayr L., F. Grabherr, J. Schwärzler, I. Reitmeier, F. Sommer, T. Gehmacher, L. Niederreiter., G.-W. He, B. Ruder, K.T.R. Kunz, P. Tymoszuk, R. Hilbe, D. Haschka, C. Feistritzer, R.R. Gerner, B. Enrich, N. Przysiecki, M. Seifert, M. Keller, G. Oberhuber, S. Sprung, Q. Ran, R. Koch, M. Effenberger, I. Tancevski, H. Zoller, A.R. Moschen, G. Weiss, C. Becker, P. Rosenstiel, A. Kaser, H. Tilg, T.E. Adolph. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease. Nature Comm. 2020.  11(1):1775.

Ruder B., C. Günther, M. Stürzl, M.F. Neurath, E. Cesarman, G. Ballon, C. Becker. Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo. PLOS one. 2020. 15(1):e0228441.

Stolzer, I., V. Kaden-Volynets, B. Ruder, M. Bittel, P. Rausch, M. Basic, A. Bleich, J.F. Baines, M.F. Neurath, S. Wirtz, S.C. Bischoff, C. Becker*, C. Günther*. Environmental microbial factors determine the pattern of inflammatory lesions in a murine model of Crohn´s disease like inflammation. Inflamm Bowel Dis. 2020.  26(1):66-79.

Bardenbacher M, B. Ruder, N. Britzen-Laurent, E. Naschberger, C. Becker, R. Palmisano, M. Stürzl, P. Tripal. Investigating Intestinal Barrier Breakdown in Living Organoids. J Vis Exp. 2020. 26;(157).


2019

Günther C., B. Ruder, I. Stolzer, H. Dorner, G.W. He, M.T. Chiriac, K. Aden, A. Strigli, M. Bittel, S. Zeissig, P. Rosenstiel, R. Atreya, M.F. Neurath, S. Wirtz, C. Becker. Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease.Gastroenterology. 2019. 157(5):1310-1322.e13.

Gößwein S., A. Lindemann, A. Mahajan, C. Maueröder, E. Martini, J. Patankar, G. Schett, C. Becker, S. Wirtz, N. Naumann-Bartsch, M.E. Bianchi, P.A. Greer, G. Lochnit, M. Herrmann, M.F. Neurath, M. Leppkes. Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation. Front Immunol. 2019. 10:2481.

Langer V, E Vivi, D Regensburger, T H Winkler, M J Waldner, T Rath, B Schmid, L Skottke, S Lee, N L Jeon, T Wohlfahrt, V Kramer, P Tripal, M Schumann, S Kersting, C Handtrack, C I Geppert, K Suchowski, R H Adams, C Becker, A Ramming, E Naschberger, N Britzen-Laurent and M Stürzl. IFN-gamma drives IBD pathogenesis through VE-cadherin-directed vascular barrier disruption. J Clin Invest. 2019. 129(11):4691-4707.

Eftychi C., R. Schwarzer, K. Vlantis, L. Wachsmuth, M. Basic, P. Wagle, M.F. Neurath, C. Becker, A. Bleich, M. Pasparakis. Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. Immunity. 2019. 51(2):367-380.

Stolzer I., Kaden-Volynets V., Ruder B., Letizia M., Bittel M., Rausch P., Basic M., Bleich A., Baines J.F., Neurath M.F., Wirtz S., Weidinger C., Bischoff S.C., Becker C*. and Günther C*. Environmental microbial factors determine the pattern of inflammatory lesions in a murine model of Crohn´s disease like inflammation. Inflammatory Bowel Diseases. 2019. Jul 5. pii: izz142. doi: 10.1093/ibd/izz142. *Shared senior authorship

Ganzleben I., He G.W., Günther C., Prigge E.-S., Richter K, Rieker R.J., Mougiakakos D., Neurath M.F., Becker C. PGAM5-dependent mitophagy is a key mediator of experimental lung inflammation and fibrosis. Cell Mol Life Sci. 2019. 76(23):4783-4794.

Kaden-Voynets V., C. Günther, J. Zimmermann, J. Beisner, C. Becker, S.C. Bischoff, Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction and malassimilation, which can be partially attenuated by inulin or butyrate. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2019. 317(4):G493-G507.  

Bardenbacher M., Ruder B., Britzen-Laurent N., Schmidt B., Waldner M., Naschberger E. Scharl M., Becker C., Stürzl M., Tripal P.   Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.  Stem Cell Research. 2019. 35:101383.

Schubart C., B. Krljanac, M. Otte, C. Symowski, E. Martini, C. Günther, C. Becker, C. Daniel and D. Voehringer. Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths.  Mucosal Immunol. 2019.  12(2):413-424

Ruder B., R. Atreya, C. Becker. Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases.  Int J Mol Sci. 2019. 20(8).


2018

Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C. Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells. Mucosal Immunol. 2018. 11(6):1621-1629

Leppkes M., Siegmund B., Becker C. Immune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing. Front Immunol. 2018. 9:1171.

Fuchslocher C.J., Falk-Paulsen M., Luzius A., Saggau C., Ruder B., Bolik J., Schmidt-Arras D., Linkermann A., Becker C., Rosenstiel P., Rose-John S., Adam D. The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. Oncotarget. 2018. 9(16):12941-12958.

Khalil M., Alliger K., Weidinger C., Yerinde C., Wirtz S., Becker C., Engel M.A. Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia. Front Immunol. 2018. 9:174.


2017

Nold-Petry C.A., Nold M.F., Levy O., Kliger Y., Oren A., Borukhov I., Becker C., Wirtz S., Sandhu M.K., Neurath M., Dinarello C.A. Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation. Front. Immunol. 2017. 8:1531.

He G.-W., Günther C., Thonn V., Yu Y.-Q., Martini E., Buchen B., Neurath M.F., Stürzl M., Becker C. Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med. 2017.  214(6):1655-1662. 

Chiriac M.T., M. Mahapatro, M.F. Neurath, C. Becker. The Microbiome in Visceral Medicine: Inflammatory Bowel Disease, Obesity and Beyond. Visceral Medicine. 2017. 33(2):153-162.

Buchheister S., M. Buettner, M. Basic, A. Noack, G. Breves, B. Buchen, L.M. Keubler, C. Becker, A. Bleich. CD14 plays a protective role in experimental inflammatory bowel disease by enhancing intestinal barrier function. Am J Pathol. 2017. 187(5):1106-1120.

Chiriac M.T., Buchen B., Wandersee A., Hundorfean G., Günther G., Bourjau Y., Doyle S.E., Frey B., Ekici A.B., Büttner C., Weigmann B., Atreya R., Wirtz S., Becker C., Siebler J., Neurath M.F. Activation of epithelial STAT1 by Interleukin 28 controls mucosal healing in mice with colitis and is increased in mucosa of patients with inflammatory bowel disease. Gastroenterology. 2017. 33(2):153-162.

Martini E, S. Krug, B. Siegmund, M.F. Neurath, C. Becker. Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017. 4(1):33-46.

Pfeifle R., T. Rothe, N. Ipseiz, H.U. Scherer, S. Culemann, U. Harre, J.A. Ackermann, M. Seefried, A. Kleyer, S. Uderhardt, B. Haugg, A.J.Hueber, P. Daum, G.F. Heidkamp, C. Ge, S. Böhm, A. Lux, W. Schuh, I. Magorivska, K.S. Nandakumar, E. Lönnblom, C. Becker, D. Dudziak, M. Wuhrer, Y. Rombouts, C.A. Koeleman, R. Toes, T.H. Winkler, R. Holmdahl, M. Herrmann, S. Blüml, F. Nimmerjahn, G. Schett, G. Krönke. Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease Nature Immunol.  2017. 18(1):104-113.

He, G.-W., C. Günther, A.E. Kremer, V. Thonn, K. Amann, C. Poremba, M.F. Neurath, S. Wirtz, C. Becker. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 2017. 66(4):716-723.


2016

Günther C., G.-W. He, A.E. Kremer, J. Murphy, E.J. Petrie, K. Amann, P. Vandenabeele, A. Linkermann, C. Poremba, U. Schleicher, C. Dewitz, S. Krautwald, M.F. Neurath, C. Becker* and S. Wirtz*. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016. 126(11):4346-4360. *Shared senior authors

Martini E., E. Schneider, C. Neufert, M.F. Neurath, C. Becker. Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β. Cell Cycle. 2016. Oct 7:1-7.

Kistner K., N. Siklosi, A. Babes, M. Khalil, T. Selescu, K. Zimmermann, S. Wirtz, C. Becker, M.F. Neurath, P.W. Reeh, M.A. Engel. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Sci Rep. 2016. 6:28621.

Mahapatro, M., Försch, S., Hefele, M., G.-W. He ,E. Giner-Ventura, T. Mchedlidze , M. Kindermann , S. Vetrano, S. Danese, C. Günther, M. F. Neurath, S. Wirtz, C. Becker. Programming of intestinal epithelial differentiation by IL-33 derived from pericryptal fibroblasts in response to systemic infection. Cell Rep. 2016. 15(8):1743-56.

Leppkes M., C. Maueröder, S. Hirth, S. Nowecki, C. Günther, U. Billmeier, S. Paulus, M. Biermann, L.E. Munoz, M. Hoffmann, D. Wildner, A.L. Croxford, A. Waisman, K. Mowen, D.E. Jenne, V. Krenn, J. Mayerle, M.M. Lerch, G. Schett, S. Wirtz, M.F. Neurath, M. Herrmann, C. Becker. Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis. Nature Comm. 2016. 7:10973.

Khalil M., A. Babes, R. Lakra, S. Försch, P.W. Reeh, S. Wirtz, C. Becker, M.F. Neurath, M.A. Engel. Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production. Mucosal Immunol. 2016. 9(6):1500-1513.

Martini E., N. Wittkopf, C. Günther, H. Okada, A. Watson, E. Podstawa, I. Backert, M.F. Neurath, C. Becker.  Loss of Survivin in intestinal epithelial progenitor cells leads to mitotic catastrophe and breakdown of gut immune homeostasis. Cell Rep. 2016. 14(5):1062-73.

Klionsky D.J., K. Abdelmohsen, A. Abe, M.J. Abedin, H. Abeliovich, A. Acevedo Arozena,...C. Becker… et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy. 2016. 12(1):1-222.

López-Posadas R., C. Becker, C. Günther, S. Tenzer, K. Amann, U. Billmeier, R. Atreya, G. Fiorino, S. Vetrano, S. Danese, A.B Ekici, S. Wirtz, V. Thonn, A.J.M. Watson, C. Brakebusch, M. Bergö, M.F. Neurath and I. Atreya. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest. 2016. 126(2):611-26.

Roulis M., G. Bongers, M. Armaka, T. Salviano, Z. He, A. Singh, U. Seidler, C. Becker, J. Demengeot, G. Furtado, S.A. Lira, G. Kollias. Host and microbiota interactions are critical for development of murine Crohn's-like ileitis. Mucosal Immunology. 2016. 9(3):787-97.

Leppkes M., M.F.Neurath, M. Herrmann, C. Becker. Immune deficiency versus immune excess in Inflammatory Bowel Diseases – STAT3 as a rheo-STAT of intestinal homeostasis. J Leukoc Biol. 2016. 99(1):57-66.

Fischer A., S. Zundler, R. Atreya, T. Rath, C. Voskens, S. Hirschmann, R. Lopez-Posadas, A. Watson, C. Becker, G. Schuler, C. Neufert, I. Atreya, M.F. Neurath. Differential effects of alpha4 beta7 and GPR15 on homing of effector and regulatory T cells from patients with ulcerative colitis to the inflamed gut in vivo. Gut. 2016. 65(10):1642-64.


2015

Genua, M., C. Becker, S. Vetrano. Anti-TNF antibodies and autophagy: a hidden nexus for a successful therapeutic response?  Journal of Crohn’s and Colitis. 2015. 10(3):237-8.

Becker C., M.F. Neurath, S. Wirtz. The intestinal microbiota in inflammatory bowel disease. ILAR J. 2015. 56(2):192-204.

Murtadak, V., C. Becker, M. Stürzl. Cell Death Inhibition by KSHV. Aging-US. 2015. 7(10):750-1.

Wittkopf N., G. Pickert,  U. Billmeier, M. Mahapatro, S. Wirtz, E. Martini, M. Leppkes, M.F. Neurath, C. Becker.  Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection. PLOS one. 2015. 10(3):e0118401

Günther C., B. Buchen, G. He, M. Hornef, N. Torow, H. Neumann, N. Wittkopf, E. Martini, M. Basic, A. Bleich, A.J. Watson, M.F. Neurath, C. Becker.  Caspase-8 controls the gut response to microbial challenges by TNFalpha -dependent and –independent pathways. Gut. 2015. 64(4):601-610

Nalleweg, N, M.T. Chiriac, E. Podstawa, C. Lehmann, T. Rau, R. Atreya, E. Krauss, G. Hundorfean, S. Fichtner-Feigl, A. Hartmann, C. Becker, J. Mudter. IL-9 and its receptor are critically involved in the pathogenesis of ulcerative colitis. Gut. 2015. 64(5):743-55.

Kreiser S., J. Eckhardt, C. Kuhnt, M. Stein, L. Krzyzak, C. Staab, C. Tucher, I. Knippertz, C. Becker, C. Günther, A. Steinkasserer, M. Lechmann. Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo. Immunobiology. 2015. 220(2):270-9.


2014

Roulis, M., C. Nikolaou, E. Kotsaki, V. Koliaraki, K. Salpea, J. Ragoussis, E. Martini, C. Becker, H.R. Herschman, S. Vetrano,S. Danese, G. Kollias. An intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014. 111(43):E4658-67.

Takahashi, N., L. Vereecke, M.J.M. Bertrand, L. Duprez, S.B. Berger, T. Divert, A. Goncalves, M. Sze, B. Gilbert, S. Kourula, V. Goossens, S. Lefevre, C. Günther, C. Becker, J. Bertin, P.J. Gough, W. Declercq, G. van Loo, P. Vandenabeele.  RIPK1 ensures intestinal homeostasis by  protecting the epithelium against apoptosis. Nature. 2014. 513(7516):95-9.

Backert I., S.B. Koralov, S. Wirtz, V. Kitowski, U. Billmeier, E. Martini, K. Hofmann, K. Hildner, N. Wittkopf, K. Brecht, M. Waldner, K. Rajewsky, M.F. Neurath, C. Becker, C. Neufert. STAT3 activation in Th17 and Th22 cells controls IL-22 mediated epithelial host defence during infectious colitis. J Immunol. 2014. 193(7):3779-91.

Leppkes M., Roulis, M. M. F. Neurath, Kollias, G. C. Becker. The pleiotropic functions of TNF-alpha in the regulation of the intestinal epithelial response to inflammation. Int Immunol. 2014. 26(9):509-515.

Günther, C., B. Buchen, M.F. Neurath, C. Becker. Regulation and pathophysiological role of epithelial turnover in the gut. Semin Cell Dev Biol. 2014. 35C:40-50.

Wittkopf N., M.F. Neurath, C. Becker. Immune-epithelial crosstalk at the intestinal surface. J Gastroenterol. 2014. 49(3):375-87.

Eckhardt J., S. Kreiser,  M. Döbbeler, C. Nicolette, M.A. DeBenedette, I.Y. Tcherepanova, C. Ostalecki, A.J. Pommer, C. Becker, C. Günther, E. Zinser, T.W. Mak, A. Steinkasserer, M. Soluble CD83 Ameliorates Experimental Colitis in Mice. Mucosal Immunology. 2014. 7(4):1006-18.


2013

Wittkopf N., C. Günther, E. Martini, G. He, K. Amann, Y.-W. He, M. Schuchmann, M.F. Neurath. C. Becker. Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8. Gastroenterology. 2013. 145(6):1369-79.

Bindea G., B. Mlecnik, M. Tosolini, A. Kirilovsky, M. Waldner, A.C. Obenauf, H. Angell, T. Fredriksen, L. Lafontaine, A. Berger, P. Bruneval, W.H. Fridman, C. Becker, F. Pagès, M.R. Speicher, Z. Trajanoski, J. Galon. Spatio-temporal dynamics of intratumoral cells reveal the immune landscape in human cancer. Immunity. 2013. 39(4):782-95.

Katt J., D. Schwinge, I. Sobottka, A. Quaas, E. Burandt, C. Becker, M.F. Neurath, A.W. Lohse, J. Herkel, C. Schramm.  Increased Th17 Response After Pathogen Stimulation in Patients with Primary Sclerotising Cholangitis. Hepatology. 2013. 58(3):1084-93.

Neufert C., C. Becker, Ö. Türeci, M.J. Waldner, I. Backert, K. Floh, I. Atreya, M. Leppkes, A. Jefremow, M. Vieth, R. Schneider-Stock, P. Klinger, F.R. Greten, D.W. Threadgill, U. Sahin, M.F. Neurath, Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasias through Erk-mediated hyperproliferative repair.  J Clin Invest. 2013. 123(4):1428-43.

Neumann H, Günther C, Vieth M, Grauer M, Wittkopf N, Mudter J, Becker C, Schoerner C, Atreya R, Neurath MF. Confocal Laser Endomicroscopy for In Vivo Diagnosis of Clostridium difficile Associated Colitis - A Pilot Study. PLoS One. 2013. 8(3):e58753.

Becker C., A.J. Watson, M.F.Neurath. The Intricate Role of Caspases in the Pathogenesis of Inflammatory Bowel Disease. Gastroenterology. 2013. 144(2):283-93.

Pickert G., H.-Y. Lim, A. Weigert, A. Häussler, T. Myrczek, M.J. Waldner, S. Labocha, N. Ferreiros-Bouzas, G. Geisslinger, J. Lotsch, C. Becker, B. Brüne, I. Tegeder. Inhibition of GTP cyclohydrolase attenuates tumor growth, angiogenesis and M2-like polarization of tumor associated macrophages. Int J Cancer. 2013. 132(3):591-604.

Günther C., H. Neumann, M.F. Neurath, C. Becker. Apoptosis, necrosis and necroptosis: Cell death regulation in the intestinal epithelium. Gut. 2013. 62(7):1062-71.


2012

Neumann H., N. Wittkopf, R. Atreya, C. Becker, M. Vieth, M.F. Neurath. Advanced endoscopic imaging: from the top of the fold to the single bacterium. Gastrointest Endosc. 2012. 75(6):1268-9.

Dornhoff H., C. Becker, J. Markl, J. Siebler, M.F. Neurath. A novel variant of the E3 ubiquitin ligase Smurf2 protects mice from colitis-associated colon cancer via the TGF-beta signaling pathway. Gastroenterology. 2012. 142(5):1183-1194.

Wittkopf, N., C. Günther, E..Martini, M. Waldner, M.F. Neurath and C. Becker. Lack of intestinal epithelial Atg7 affects Paneth cell granule formation but does not compromise immune homeostasis in the gut. Clin Dev Immunol. 2012. 2012:278059.

Weigmann B., N. Schughart, C. Wiebe, S. Sudowe, H. Jonuleit, L. Vogel, C. Becker, M.F. Neurath, S. Grabbe, J. Saloga, I. Bellinghausen. Allergen-induced IgE-dependent gut inflammation in a humanized mouse model of allergy. J Allergy Clin Immunol. 2012. 129(4):1126-35.

Engel M.A., M. Khalil, N. Siklosi, S.M. Mueller-Tribbensee, W.L. Neuhuber, M.F. Neurath, C. Becker, P.W. Reeh. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Dig Liver Dis. 2012. 44(1):24-9. 

Engel M., M. Khalil, S.M. Mueller-Tribbensee, C. Becker, W.L. Neuhuber, M.F. Neurath, P.W. Reeh. The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons. J Gastroenterology. 2012. 47(3):256-65.

Torzewski M., P. Wenzel, H. Kleinert, C. Becker, J. El-Masri, E. Wiese, M. Brandt, A. Pautz, L. Twardowski, E. Schmitt, T. Münzel, K. Reifenberg. Chronic Inflammatory Cardiomyopathy of Interferon γ-Overexpressing Transgenic Mice Is Mediated by Tumor Necrosis Factor-alpha. Am J Pathol. 2012. 180(1):73-81.  


2011

Günther C., E. Martini, N. Wittkopf, K. Amann, B. Weigmann, H. Neumann, M.J. Waldner, S.M. Hedrick, S. Tenzer, M.F. Neurath, C. Becker. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature. 2011. 477(7364):335-9.

Rizzo A., M.J. Waldner, C. Stolfi, M. Sarra, D. Fina, C. Becker, M.F. Neurath, T.T. Macdonald, F. Pallone, G. Monteleone, M.C. Fantini. Smad7 expression in T cells prevents colitis-associated cancer. Cancer Res. 2011. 71(24):7423-32.

 Engel M.A., A. Leffler, F. Niedermirtl, A. Babes, K. Zimmermann, M.R. Filipović, I. Izydorczyk, M. Eberhardt, T.I. Kichko, S.M. Mueller-Tribbensee, M. Khalil, N. Siklosi, C. Nau, I. Ivanović-Burmazović, W.L. Neuhuber, C. Becker, M.F. Neurath, P.W. Reeh. TRPA1 and Substance P Mediate Colitis in Mice. Gastroenterology. 2011. 141(4):1346-58.

Waldner M.J., S. Wirtz, C. Neufert, C. Becker, M.F. Neurath. Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice. Nat Protoc. 2011. 6(9):1471-81.

Engel M.A., C. Becker, P.W. Reeh, M.F. Neurath. Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut. Inflamm Bowel Dis. 2011. 17(4):1030-3.


Auswahl älterer Veröffentlichungen (2003-2010)

Neurath M.F., N. Wittkopf, A. Wlodarski, M.J. Waldner, C. Neufert, S. Wirtz, C. Günther, C. Becker. Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology. 2010. 139(6):1837-1843

Chalaris A., N. Adam, C. Sina, P. Rosenstiel, J. Lehmann, P. Schirmacher, D. Hartmann, J. Cichy, O. Gawrilova, S. Schreiber, T. Jostock, V. Mathews, R. Hässler, C. Becker, M.F. Neurath, K. Reiss, P. Saftig, J. Scheller, S. Rose-John. Inflammation and Regeneration are orchestrated by the Disintegrin Metalloprotease Adam17. J. Exp. Med. 2010. 207(8):1617-24.

Neufert C, G. Pickert, Y.Zheng, N. Wittkopf, M. Warntjen, A. Nikolaev, W. Ouyang, Markus F. Neurath, C. Becker. Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle. 2010. 9(4):652-55

Pickert G, C. Neufert, M. Leppkes, Y. Zheng, N. Wittkopf, M. Warntjen, H.-A. Lehr, S. Hirth, B. Weigmann, S. Wirtz., W. Ouyang, M.F. Neurath, C. Becker. STAT3 links IL-22 signalling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 2009. 206(7):1465-72.
 
Leppkes M* und C. Becker*, I.I. Ivanov, S. Hirth, S. Wirtz, C. Neufert, S. Pouly, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, B. Becher, D.R. Littman, Markus F. Neurath. RORgamma-Expressing Th17 cells Induce Murine Chronic Intestinal Inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009. 136(1):257-67.

Dominitzki S., M.C. Fantini, C. Neufert, A. Nikolaev, P.R. Galle, J. Scheller, G. Monteleone, S. Rose-John, M.F. Neurath, C. Becker. Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells. J Immunol. 2007. 179(4):2041-5.

Fantini M.C., S. Dominitzki, A. Rizzo, M.F. Neurath, C. Becker. In vitro generation of CD4+CD25+ regulatory cells from murine naïve T cells. Nature Protocols. 2007. 2(7):1789-94. 

Nenci A* und C. Becker*, A. Wullaert, R. Gareus, G. van Loo, S. Danese, M. Huth, A. Nikolaev, C. Neufert, B. Madison, D. Gumucio, M.F. Neurath, M. Pasparakis. Epithelial NEMO/IKK-gamma links innate immunity to chronic intestinal inflammation. Nature. 2007. 29;446(7135):55761.

Becker, C., M.C. Fantini, M.F. Neurath. High resolution colonoscopy in live mice. Nature Protocols. 2006. 1(6):2900-04.

Becker, C., H. Dornhoff, C. Neufert, M.C. Fantini, S. Wirtz, D. Strand, A. Nikolaev, H.A.Lehr, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, M. Karow, P.R. Galle, M.F. Neurath. IL-23 cross regulates IL-12 production in T cell dependent experimental colitis. J Immunol. 2006. 177(5):2760-4.

Becker, C., M.C. Fantini, M.F. Neurath. TGF-beta as an immune regulator in Colitis and Colon Cancer. Cytokine Growth Factor Rev. 2006. 17:97-106.

Becker, C., M.C. Fantini, S. Wirtz, A. Nikolaev , R. Kiesslich, H.A.Lehr, P.R. Galle, M.F. Neurath. In vivo imaging of colitis associated colon cancer in mice using high resolution chromoendoscopy. Gut. 2005. 54: 950-954.

Becker, C., M.C. Fantini,  H.A. Lehr, S. Wirtz, A. Nikolaev, P.R. Galle, S. Rose-John, M.F. Neurath. IL-6 signaling promotes tumor growth in colon cancer. Cell Cycle. 2005. 4(2) 35-38.
         
Becker, C., S. Wirtz, M.F. Neurath. Stepwise regulation of TH1 responses in autoimmunity: IL-12 related cytokines and their receptors. Inflamm Bowel Dis. 2005. 11(8):755-64.

Becker, C.*, M.C. Fantini*, C. Schramm, H.A. Lehr, S. Wirtz, A. Nikolaev, J. Burg, S. Strand, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, P.R. Galle,M. Blessing, S. Rose-John and M.F. Neurath. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity. 2004. 21(4): 491-501.

Fantini M.C., C. Becker, G. Monteleone, F. Pallone, P.R. Galle, M.F. Neurath. TGF-beta Induces a Regulatory Phenotype in CD4+CD25– T Cells through Foxp3 Induction and Down-Regulation of Smad7. J.Immunol. 2004. 172: 5149-5153.

Becker, C, Wirtz, S., Blessing, M., Pirhonen, J., Strand, D., Bechthold, O., Frick, J., Galle, P.R., Autenrieth, I., Neurath, M.F. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest. 2003. 112(5):693-706.