Publikationen

Medizin 1

Direktor:
Prof. Dr. med. Markus F. Neurath

Arbeitsgruppe Therapeutische Immunsuppression: Molekulare Mechanismen und experimentelle Strategien

Ausgewählte Publikationen

Schulz-Kuhnt A, Wirtz S, Neurath MF, Atreya I, “Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation” Front Immunol. 2020 Jun 23;11:1062.

A. Schulz-Kuhnt, V. Greif, K. Hildner, L. Knipfer, M. Döbrönti, S. Zirlik, F Fuchs, R. Atreya, S. Zundler, R. López-Posadas, C. Neufert, A. Ramming, A. Kiefer, A. Grüneboom, E. Strasser, S. Wirtz, M. F. Neurath*, I. Atreya*, “ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure” Front Immunol. 2020, 11, 691.

L. Knipfer, A. Schulz-Kuhnt, M. Kindermann, V. Greif, C. Symowski, D. Voehringer, M. F. Neurath, I. Atreya, S. Wirtz, “A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation” J. Exp. Med. 2019, 216, 2763-2777.

R. López-Posadas, P. Fastancz, L. D. C. Martínez-Sánchez, J. Panteleev-Ivlev, V. Thonn, T. Kisseleva, L. S. Becker, A. Schulz-Kuhnt, S. Zundler, S. Wirtz, R. Atreya, B. Carlé, O. Friedrich, S. Schürmann, M. J. Waldner, C. Neufert, C. H. Brakebusch, M. O. Bergö, M. F. Neurath*, I. Atreya*, “Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice” Gastroenterol. 2019, 157, 1293-1309.

A. Schulz-Kuhnt, S. Zundler, A. Grüneboom, C. Neufert, S. Wirtz, M. F. Neurath, I. Atreya, “Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy” J. Vis. Exp. 2019, 146, e59043

S. Zundler, E. Becker, M. Spocinska, M. Slawik, L. Parga-Vidal, R. Stark, M. Wiendl, R. Atreya, T. Rath, M. Leppkes, K. Hildner, R. López-Posadas, S. Lukassen, A. B. Ekici, C. Neufert, I. Atreya, K. P. J. M van Gisbergen, M. F. Neurath, “Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation” Nat. Immunol. 2019, 20, 288-300.

R. López-Posadas, M. F. Neurath, I. Atreya, “Molecular pathways driving disease-specific alterations of intestinal epithelial cells” Cell. Mol. Life Sci. 2017, 74, 803-826.

I. Atreya, M. F. Neurath, “Microbiota: relevant player in thiopurine metabolisation?” Gut. 2017, 66(1), 1-3.

I. Atreya, A. Diall, R. Dvorsky, R. Atreya, C. Henninger, M. Grün, U. Hofmann, E. Schaeffeler, R. López-Posadas, I. Daehn, S. Zenker, M. Döbrönti, C. Neufert, U. Billmeier, S. Zundler, G. Fritz, M. Schwab, M. F. Neurath, “Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases” J. Crohns Colitis 2016, 10, 1132-43.

R. López-Posadas, C, Becker, C. Günther, S. Tenzer, K. Amann, U. Billmeier, R. Atreya, G. Fiorino, S. Vetrano, S. Danese, A. B. Ekici, S. Wirtz, V. Thonn, A. J. Watson, C. Brakebusch, M. Bergö, M. F. Neurath*, I. Atreya*, “Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation” J. Clin. Invest. 2016; 126, 611-26.

A. Fischer, S. Zundler, R. Atreya, T. Rath, C. Voskens, S. Hirschmann, R. López-Posadas, A. Watson, C. Becker, G. Schuler, C. Neufert*, I. Atreya*, M. F. Neurath*, “Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo” Gut. 2016, 65, 1642-64.

Tiede I (now: Atreya I), Fritz G, Strand S, Poppe D, Dvorsky R, Strand D, Lehr HA, Wirtz S, Becker C, Atreya R, Mudter J, Hildner K, Bartsch B, Holtmann M, Blumberg R, Walczak H, Iven H, Galle PR, Ahmadian MR, Neurath MF, “CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes” J Clin Invest. 2003 Apr;111(8):1133-45.